Figure 6

Differentially expressed genes that suppress the temperature sensitivity of cdc13-1. (a) Genes that were differentially expressed in cdc13-1 strains and those that suppress cdc13-1 temperature sensitivity [35] were plotted using a Venn diagram. (b) Normalized BNA2 expression values from the microarray experiment are plotted as in Figure 3. (c) Functional interactions between BNA2 and genes differentially expressed in cdc13-1 strains or whose deletion suppresses temperature sensitivity of cdc13-1 were identified and visualized using Biogrid and OSPREY. Nodes shown in light grey represent genes from the cdc13-1 microarray data set, while nodes shown in dark grey represent genes whose deletion suppresses cdc13-1 temperature sensitivity. Edges represent functional interactions. The edge connecting BNA2 and NPT1 represents a 'synthetic lethality' interaction.