Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools

Table 1 Occurrences of PAX2/5/8 candidate target genes predicted from matrices A and B in mouse (GXD) and zebrafish (ZFIN) databases

	Matrix A	Matrix B	Matrices A+B	Total genes
Candidate genes	486	195	672	22,242
Genes described in GXD	209	96	301	7,080
Genes described in ZFIN	135	55	188	5,623
Genes described in GXD and ZFIN	274	122	392	10,082
Genes expressed in ear in GXD	52	14	66	1,267
Genes expressed in ear in ZFIN	18	6	24	5,72
Genes expressed in ear in GXD and ZFIN	64	19	83	1,717

Numbers in bold are the values used to construct the contingency table, used for the calculation of the over-representation of genes expressed in the otic.

ISSN: 1474-760X