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Table 10 Comparison of the transcriptome of human GM-CSF monocyte-derived DCs to that of blood DCs

From: Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

   

Ratio to monocytes

Probe set ID

Name

Mono

PBMC-MΦ

mo-MΦ

mo-DC

CD16

BDCA3

BDCA1

pDCs

Myeloid signature genes

         

222934_s_at

CLEC4E

2,358

0.20

0.19

0.04

-

-

0.05

-

209930_s_at

NFE2

823

0.06

0.06

0.89

0.10

-

0.06

-

202974_at

MPP1

3,622

0.40

1.25

0.68

0.33

0.08

0.15

0.11

205098_at

CCR1

3,528

0.76

1.63

1.83

0.03

-

0.03

0.03

203535_at

S100A9

11,192

0.05

0.37

0.01

0.12

0.02

0.17

0.01

201743_at

CD14

8,096

0.44

1.13

0.34

0.01

-

0.02

0.01

224341_x_at

TLR4

1,417

0.13

1.10

0.35

0.34

-

0.06

-

203561_at

FCGR2A

2,946

0.18

0.80

1.36

0.85

-

0.33

0.02

204924_at

TLR2

3,220

0.14

0.80

0.32

0.54

0.08

0.31

0.02

218739_at

ABHD5

285

0.35

0.99

0.67

0.33

-

-

-

201089_at

ATP6V1B2

3,178

2.05

2.46

1.70

0.66

0.12

0.34

0.21

201631_s_at

IER3

2,042

0.42

1.74

0.82

0.10

0.06

0.14

0.12

222218_s_at

PILRA

2,709

0.73

1.24

1.23

1.25

0.05

0.39

0.05

210423_s_at

SLC11A1

1,713

0.47

0.82

0.25

1.75

0.04

0.05

-

203045_at

NINJ1

1,190

1.69

3.59

3.41

1.59

0.27

0.44

0.26

200958_s_at

SDCBP

11,323

0.87

1.16

0.90

0.61

0.33

0.40

0.26

202917_s_at

S100A8

15,661

0.02

0.41

0.01

0.11

0.01

0.27

0.03

217748_at

ADIPOR1

2,229

0.57

0.48

1.16

0.30

0.30

0.36

0.28

201669_s_at

MARCKS

2,340

0.84

2.57

1.57

0.65

0.16

0.20

-

207697_x_at

LILRB2

3,260

0.29

0.64

0.76

1.36

0.02

0.39

0.24

228220_at

FCHO2

619

4.50

4.04

3.62

0.76

0.35

0.26

0.23

1553297_a_at

CSF3R

3,121

0.42

0.69

0.37

0.08

0.11

0.52

0.04

220088_at

C5AR1

2,059

2.56

3.63

1.30

1.60

-

0.03

0.04

212501_at

CEBPB

3,490

3.26

3.23

3.30

1.26

0.06

0.49

0.06

221698_s_at

CLEC7A

6,596

0.24

0.55

0.63

0.74

0.62

0.46

0.01

209551_at

YIPF4

526

0.85

1.65

1.91

0.41

0.37

0.44

0.37

204204_at

SLC31A2

1,933

0.94

1.14

0.69

0.76

0.10

0.22

0.03

Pan-DC signature genes

         

206674_at

FLT3

221

-

-

-

-

24.01

12.76

9.26

219256_s_at

SH3TC1

395

1.02

2.73

1.12

2.01

2.22

3.01

2.86

218617_at

TRIT1

498

0.49

0.58

0.86

0.71

2.46

2.15

3.61

231810_at

BRI3BP

301

0.98

1.42

1.99

0.98

2.35

2.10

2.70

209139_s_at

PRKRA

325

1.12

1.77

1.47

1.57

3.17

2.42

4.37

225764_at

ETV6

1,097

0.43

1.13

2.00

0.75

2.04

1.78

1.48

208837_at

TMED3

595

1.50

2.81

1.64

1.46

2.91

1.98

2.94

219218_at

BAHCC1

-

-

-

-

-

>1.7

>1.5

>4.7

1552256_a_at

SCARB1

151

8.98

6.58

7.21

-

2.33

1.70

5.30

cDC signature genes

         

206298_at

ARHGAP22

-

>5.8

>6.5

>3.1

-

>6.2

>4.6

-

227329_at

BTBD4

-

>1.6

>2.8

>5.8

-

>9.3

>8.7

-

219386_s_at

SLAMF8

98

24.75

38.66

23.99

0.51

15.48

5.30

0.51

220358_at

SNFT

148

0.62

0.34

8.62

5.66

16.01

4.82

0.34

224772_at

NAV1

64

2.01

3.25

1.40

2.00

23.87

10.50

1.62

205101_at

CIITA

481

0.29

0.12

1.09

0.48

4.51

5.28

1.43

218631_at

AVPI1

-

>18.7

>31.3

>64.8

>1.6

>3.2

>7.0

-

202826_at

SPINT1

84

4.65

7.15

8.79

0.90

2.59

2.92

0.68

208660_at

CS

1,848

1.24

0.99

1.04

0.84

1.70

1.63

0.89

APC signature genes

         

203932_at

HLA-DMB

5,137

1.28

0.64

1.37

0.44

1.45

1.62

1.14

219574_at

MARCH1

1,133

0.42

0.89

0.73

0.62

0.64

0.44

0.46

201425_at

ALDH2

8,782

0.51

0.54

0.34

0.18

0.84

1.01

0.69

222891_s_at

BCL11A

310

0.98

0.34

0.50

0.74

2.40

1.73

14.23

205504_at

BTK

1,372

0.29

0.47

0.64

1.13

0.58

0.75

0.81

202295_s_at

CTSH

3,755

1.76

2.37

2.09

0.56

0.63

1.57

0.31

209312_x_at

HLA-DRB1

12,737

1.02

0.57

1.34

1.11

1.12

1.11

1.00

209619_at

CD74

8,540

1.49

0.86

2.12

0.73

1.33

1.34

1.11

210042_s_at

CTSZ

369

0.76

1.13

17.00

1.66

2.13

2.17

1.83

201560_at

CLIC4

2,828

0.87

0.88

1.00

0.12

0.10

0.28

0.22

217388_s_at

KYNU

3,429

1.50

1.95

0.90

0.94

0.30

0.65

0.63

217118_s_at

C22orf9

1,617

3.33

3.46

2.77

1.43

1.85

1.79

1.04

203927_at

NFKBIE

173

3.30

9.96

3.13

1.45

1.39

2.60

1.25

220998_s_at

UNC93B1

847

0.60

1.31

0.97

1.31

0.99

1.06

2.27

Non-DC signature genes

         

219243_at

GIMAP4

4,384

0.15

0.11

0.19

0.27

-

-

-

221704_s_at

VPS37B

559

0.26

0.90

0.47

0.80

-

-

-

204891_s_at

LCK

96

1.48

0.52

0.52

0.59

-

-

-

214582_at

PDE3B

144

2.82

2.99

2.43

0.76

-

0.51

-

  1. *Average expression across replicates. Genes for which expression between monocyte-derived DCs and blood DCs or blood cDCs varies more than two-fold are shown in bold. mo-DC, monocyte-derived GM-CSF DC; mo-MΦ, monocyte-derived M-CSF macrophages; mono, monocyte; PBMC-MΦ, human peripheral blood mononuclear cell-derived M-CSF macrophages.
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Genome Biology

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