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Table 10 Comparison of the transcriptome of human GM-CSF monocyte-derived DCs to that of blood DCs

From: Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

    Ratio to monocytes
Probe set ID Name Mono PBMC-MΦ mo-MΦ mo-DC CD16 BDCA3 BDCA1 pDCs
Myeloid signature genes          
222934_s_at CLEC4E 2,358 0.20 0.19 0.04 - - 0.05 -
209930_s_at NFE2 823 0.06 0.06 0.89 0.10 - 0.06 -
202974_at MPP1 3,622 0.40 1.25 0.68 0.33 0.08 0.15 0.11
205098_at CCR1 3,528 0.76 1.63 1.83 0.03 - 0.03 0.03
203535_at S100A9 11,192 0.05 0.37 0.01 0.12 0.02 0.17 0.01
201743_at CD14 8,096 0.44 1.13 0.34 0.01 - 0.02 0.01
224341_x_at TLR4 1,417 0.13 1.10 0.35 0.34 - 0.06 -
203561_at FCGR2A 2,946 0.18 0.80 1.36 0.85 - 0.33 0.02
204924_at TLR2 3,220 0.14 0.80 0.32 0.54 0.08 0.31 0.02
218739_at ABHD5 285 0.35 0.99 0.67 0.33 - - -
201089_at ATP6V1B2 3,178 2.05 2.46 1.70 0.66 0.12 0.34 0.21
201631_s_at IER3 2,042 0.42 1.74 0.82 0.10 0.06 0.14 0.12
222218_s_at PILRA 2,709 0.73 1.24 1.23 1.25 0.05 0.39 0.05
210423_s_at SLC11A1 1,713 0.47 0.82 0.25 1.75 0.04 0.05 -
203045_at NINJ1 1,190 1.69 3.59 3.41 1.59 0.27 0.44 0.26
200958_s_at SDCBP 11,323 0.87 1.16 0.90 0.61 0.33 0.40 0.26
202917_s_at S100A8 15,661 0.02 0.41 0.01 0.11 0.01 0.27 0.03
217748_at ADIPOR1 2,229 0.57 0.48 1.16 0.30 0.30 0.36 0.28
201669_s_at MARCKS 2,340 0.84 2.57 1.57 0.65 0.16 0.20 -
207697_x_at LILRB2 3,260 0.29 0.64 0.76 1.36 0.02 0.39 0.24
228220_at FCHO2 619 4.50 4.04 3.62 0.76 0.35 0.26 0.23
1553297_a_at CSF3R 3,121 0.42 0.69 0.37 0.08 0.11 0.52 0.04
220088_at C5AR1 2,059 2.56 3.63 1.30 1.60 - 0.03 0.04
212501_at CEBPB 3,490 3.26 3.23 3.30 1.26 0.06 0.49 0.06
221698_s_at CLEC7A 6,596 0.24 0.55 0.63 0.74 0.62 0.46 0.01
209551_at YIPF4 526 0.85 1.65 1.91 0.41 0.37 0.44 0.37
204204_at SLC31A2 1,933 0.94 1.14 0.69 0.76 0.10 0.22 0.03
Pan-DC signature genes          
206674_at FLT3 221 - - - - 24.01 12.76 9.26
219256_s_at SH3TC1 395 1.02 2.73 1.12 2.01 2.22 3.01 2.86
218617_at TRIT1 498 0.49 0.58 0.86 0.71 2.46 2.15 3.61
231810_at BRI3BP 301 0.98 1.42 1.99 0.98 2.35 2.10 2.70
209139_s_at PRKRA 325 1.12 1.77 1.47 1.57 3.17 2.42 4.37
225764_at ETV6 1,097 0.43 1.13 2.00 0.75 2.04 1.78 1.48
208837_at TMED3 595 1.50 2.81 1.64 1.46 2.91 1.98 2.94
219218_at BAHCC1 - - - - - >1.7 >1.5 >4.7
1552256_a_at SCARB1 151 8.98 6.58 7.21 - 2.33 1.70 5.30
cDC signature genes          
206298_at ARHGAP22 - >5.8 >6.5 >3.1 - >6.2 >4.6 -
227329_at BTBD4 - >1.6 >2.8 >5.8 - >9.3 >8.7 -
219386_s_at SLAMF8 98 24.75 38.66 23.99 0.51 15.48 5.30 0.51
220358_at SNFT 148 0.62 0.34 8.62 5.66 16.01 4.82 0.34
224772_at NAV1 64 2.01 3.25 1.40 2.00 23.87 10.50 1.62
205101_at CIITA 481 0.29 0.12 1.09 0.48 4.51 5.28 1.43
218631_at AVPI1 - >18.7 >31.3 >64.8 >1.6 >3.2 >7.0 -
202826_at SPINT1 84 4.65 7.15 8.79 0.90 2.59 2.92 0.68
208660_at CS 1,848 1.24 0.99 1.04 0.84 1.70 1.63 0.89
APC signature genes          
203932_at HLA-DMB 5,137 1.28 0.64 1.37 0.44 1.45 1.62 1.14
219574_at MARCH1 1,133 0.42 0.89 0.73 0.62 0.64 0.44 0.46
201425_at ALDH2 8,782 0.51 0.54 0.34 0.18 0.84 1.01 0.69
222891_s_at BCL11A 310 0.98 0.34 0.50 0.74 2.40 1.73 14.23
205504_at BTK 1,372 0.29 0.47 0.64 1.13 0.58 0.75 0.81
202295_s_at CTSH 3,755 1.76 2.37 2.09 0.56 0.63 1.57 0.31
209312_x_at HLA-DRB1 12,737 1.02 0.57 1.34 1.11 1.12 1.11 1.00
209619_at CD74 8,540 1.49 0.86 2.12 0.73 1.33 1.34 1.11
210042_s_at CTSZ 369 0.76 1.13 17.00 1.66 2.13 2.17 1.83
201560_at CLIC4 2,828 0.87 0.88 1.00 0.12 0.10 0.28 0.22
217388_s_at KYNU 3,429 1.50 1.95 0.90 0.94 0.30 0.65 0.63
217118_s_at C22orf9 1,617 3.33 3.46 2.77 1.43 1.85 1.79 1.04
203927_at NFKBIE 173 3.30 9.96 3.13 1.45 1.39 2.60 1.25
220998_s_at UNC93B1 847 0.60 1.31 0.97 1.31 0.99 1.06 2.27
Non-DC signature genes          
219243_at GIMAP4 4,384 0.15 0.11 0.19 0.27 - - -
221704_s_at VPS37B 559 0.26 0.90 0.47 0.80 - - -
204891_s_at LCK 96 1.48 0.52 0.52 0.59 - - -
214582_at PDE3B 144 2.82 2.99 2.43 0.76 - 0.51 -
  1. *Average expression across replicates. Genes for which expression between monocyte-derived DCs and blood DCs or blood cDCs varies more than two-fold are shown in bold. mo-DC, monocyte-derived GM-CSF DC; mo-MΦ, monocyte-derived M-CSF macrophages; mono, monocyte; PBMC-MΦ, human peripheral blood mononuclear cell-derived M-CSF macrophages.