Figure 5From: An improved method for detecting and delineating genomic regions with altered gene expression in cancerApplication to childhood ALL data. To verify the ability of the proposed method to identify genomic regions with expected increases/decreases in average gene expression, we applied it to the data set by Ross et al [26] (Affymetrix U133A+B arrays). Each case was normalized and segmented as described in Materials and methods. Blue solid: Average segmentation result across all cases of each leukemic subtype (Table 1). Orange: Average DNA copy number profile across within each class, as determined from the Mullighan et al data set [29] (Affymetrix 250 k SNP arrays). Key observation: The method successfully identified several regions with altered gene expression (details in Results). The case-specific segmentations are provided in Additional file 3. In this example, T μ = 0.25 (similar results for other reasonable values).Back to article page