Figure 7
Three-dimensional structure of one of our top predictions. A fragment of FYN with SH2 and SH3 domain is crystallized in PDB (ID: 1G83) and is visualized here. The fragment accounts for about 30% of the total protein length and is rendered in a ribbon representation. The SH2 domain, which is colored in green, is predicted to be the binding site for VAV1. The position of the potential driver mutation found in somatic cancer cells is highlighted by the white balls.