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Table 3 Transcription factor-binding motifs in promoters of loneliness-related genes

From: Social regulation of gene expression in human leukocytes

TFBM Low lonely High lonely Ratio t df p
V$CEBP_Q2 (C/EBP) 0.714 0.340 0.476 -2.76 120.3 0.0067
V$OCT1_03 (Oct) 1.400 0.793 0.566 -2.60 115.7 0.0106
V$CREL_01 (NF-κB) 0.129 0.377 2.935 2.62 74.6 0.0108
V$GATA1_03 (GATA) 0.557 0.245 0.440 -2.52 120.2 0.0131
V$OCT1_04 (Oct) 0.086 0.000 0.000 -2.54 69.0 0.0132
V$OCT_C (Oct) 0.071 0.000 0.000 -2.30 69.0 0.0242
V$AHRARNT_01 (AHR) 0.043 0.208 4.843 2.28 65.4 0.0258
V$BARBIE_01 (BARBIE) 0.043 0.208 4.843 2.28 65.4 0.0258
V$GR_Q6 (GRE) 0.257 0.094 0.367 -2.17 112.1 0.0325
V$STAT_01 (STAT) 0.014 0.151 10.566 2.13 57.4 0.0376
V$TAL1BETAE47_01 0.057 0.000 0.000 -2.04 69.0 0.0447
V$TAL1ALPHAE47_01 0.057 0.000 0.000 -2.04 69.0 0.0447
V$IRF1_01 (IRF1) 0.086 0.000 0.000 -1.93 69.0 0.0572
  1. TFBM: transcription factor-binding motif (V$ = TRANSFAC Vertebrate). Low lonely: average TFBM prevalence in promoters of genes up-regulated in low-lonely. High lonely: average TFBM prevalence in promoters of genes up-regulated in high-lonely. Ratio: high-lonely/low-lonely. t Statistic: Welch formula for unequal variances. df: continuous degrees of freedom for Welch unequal variance t-test. p value: two-tailed.