Social regulation of gene expression in human leukocytes

Table 3 Transcription factor-binding motifs in promoters of loneliness-related genes

TFBM	Low lonely	High lonely	Ratio	t	df	p
V$CEBP_Q2 (C/EBP)	0.714	0.340	0.476	-2.76	120.3	0.0067
V$OCT1_03 (Oct)	1.400	0.793	0.566	-2.60	115.7	0.0106
V$CREL_01 (NF-κB)	0.129	0.377	2.935	2.62	74.6	0.0108
V$GATA1_03 (GATA)	0.557	0.245	0.440	-2.52	120.2	0.0131
V$OCT1_04 (Oct)	0.086	0.000	0.000	-2.54	69.0	0.0132
V$OCT_C (Oct)	0.071	0.000	0.000	-2.30	69.0	0.0242
V$AHRARNT_01 (AHR)	0.043	0.208	4.843	2.28	65.4	0.0258
V$BARBIE_01 (BARBIE)	0.043	0.208	4.843	2.28	65.4	0.0258
V$GR_Q6 (GRE)	0.257	0.094	0.367	-2.17	112.1	0.0325
V$STAT_01 (STAT)	0.014	0.151	10.566	2.13	57.4	0.0376
V$TAL1BETAE47_01	0.057	0.000	0.000	-2.04	69.0	0.0447
V$TAL1ALPHAE47_01	0.057	0.000	0.000	-2.04	69.0	0.0447
V$IRF1_01 (IRF1)	0.086	0.000	0.000	-1.93	69.0	0.0572

TFBM: transcription factor-binding motif (V$ = TRANSFAC Vertebrate). Low lonely: average TFBM prevalence in promoters of genes up-regulated in low-lonely. High lonely: average TFBM prevalence in promoters of genes up-regulated in high-lonely. Ratio: high-lonely/low-lonely. t Statistic: Welch formula for unequal variances. df: continuous degrees of freedom for Welch unequal variance t-test. p value: two-tailed.

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