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Table 3 GCFS evaluated from the orthologous ProtSemNet

From: Novel metrics for evaluating the functional coherence of protein groups via protein semantic network

Protein pathway

GFCSe

P

GFCSd

P

Apoptosis (hsa04210)

72

2.54 × e-10

0.77

3.12 × e-9

Glycolysis (hsa00010)

54

0.0062

0.83

4.50 × e-4

Focal adhesion (hsa04510)

99

1.66 × e-7

0.58

1.34 × e-14

JAK-STAT (hsa04630)

153

2.19 × e-07

3.11

7.48 × e-11

ATP synthesis (mmu00190)

71

2.14 × e-4

0.83

4.28 × e-07

Calcium signaling (mmu04020)

76

4.43 × e-8

0.40

1.16 × e-12

Actin regulation (mmu04810)

80

0.0089

0.53

7.45 × e-9

Cytokine receptor (mmu04060)

199

2.63 × e-8

4.51

4.44 × e-12

Purine metabolism (sce00230)

130

2.07 × e-4

2.57

6.92 × e-19

MAPK (sce04010)

101

0.0069

1.76

1.76 × e-05

Ribosome (sce03010)

102

9.50 × e-25

7.19

0.471a

Oxidative phosphorylation (sce00190)

92

1.41 × e-6

2.87

0

  1. GFCS, group functional coherence score; JAK, Janus kinase; MAPK, mitogen-activated protein kinase; ProtSemNet, protein semantic network; STAT, signal transducer and activator of transcription. aNon-significant P value.