Meta-analysis of primary target genes of peroxisome proliferator-activated receptors

Table 3 Functionality of genomic regions

Genomic region	Predicted binding	Response in RGA	Association of PPARα	Association of RXRα	Association of pPol II	PPRE status
ACOX1 intron 1	Strong	+	+	+	+	+
APOC3 proximal	Weak	Down	+	+	+	+
APOC3 published	Medium	Down	+	+	-	+
APOA1 proximal	Weak	+/down	+	+	+	+
CPT1B	Strong	+	-	-	-	±
PPARα proximal	Medium	+	+	+	+	+
RVRα proximal	Medium	+	+	+	+	+
RVRα TSS	No DR1	-	+*	+*	+*	-
UCP3 proximal	Medium	Down	+	+	+
ACOX1 distal	Medium	-	-	-	-	-
ACOX1 published	Not binding	-	-	-	-	-
ANGPLT4 distal	Weak	+/down	+	+	-	+
APOC3 distal 1	Medium	±	-	-	-	-
APOC3 distal 2	Medium	±	-	-	-	-
PPARα distal	Strong	+/down	+	+	+	+
RVRα distal	Weak	-	+	+	-	±
SULT2A1	Strong	+	+	+	+	+
UCP3 distal	Strong	+	+	+	+	+
ACOX1 intron 2	Medium	+	+	+	+	+
ANGPTL4 cluster	Strong	+	-	+	+	+
APOC3 intron	Strong	+	-	-	-	±
UCP3 cluster	Weak	-	-	-	-	-
UCP3 intron	Medium	Down	+	+	+	+

The data from reporter gene assay (RGA) and ChIP assays are summarized for each genomic region tested. The PPRE status indicates the conclusion drawn from the assays concerning the functionality of each region, with '+' assigned to functional regions, '-' to non-functional regions and '±' where the two assays were not in agreement. *Impossible to assess independent of adjacent region.

ISSN: 1474-760X