Figure 6

SOM analysis of established primary PPAR target genes, clusters I and II. Overview of the genomic organization of 38 known human PPAR target genes (left) and their mouse orthologs (right); 10 kB upstream and downstream of the TSS are shown in this and Figure 7. Please note that for the mouse CYP1A1 gene and the human FADS2 gene, there are discrepancies between the Ensembl (E) and NCBI (N) databases; therefore, both versions are shown. Putative PPREs (red boxes, no conservation; orange boxes, within conserved area; yellow boxes, conserved) were identified by in silico screening of the genomic sequences and are classified according to their degree of conservation between mouse and human. Already published PPREs are indicated by an asterisk. For each of the predicted PPREs, the calculated binding strengths of PPARα (green), PPARγ (dark blue) and PPARβ/δ (light blue) in reference to a consensus DR1-type PPRE are represented by column height. All putative PPRE sequences are available on request. The genes were sorted by SOM analysis with respect to overall PPRE pattern similarity and their evolutionary conservation into (a) cluster I and (b) cluster II.