From: Evolutionary conservation of regulated longevity assurance mechanisms
 | Catmap p value | |||
---|---|---|---|---|
 | Worm | Fly | Mouse | |
 | daf-2 | chico | Ames | Little |
Up-regulated Gene Ontology categories | Â | Â | Â | Â |
   GO:0008150 biological process |  |  |  |  |
GO:0046365 monosaccharide catabolism | *** | ** | * | NS |
GO:0019320 hexose catabolism | *** | ** | * | NS |
GO:0006007 glucose catabolism | *** | ** | * | NS |
GO:0006090 pyruvate metabolism | * | * | ** | * |
GO:0006091 generation of precursor metabolites | * | *** | *** | *** |
GO:0015980 energy derivation by oxidation | *** | ** | * | ** |
GO:0006092 main pathways of carbohydrate metabolism | *** | ** | ** | ** |
GO:0015849 organic acid transport | * | * | * | NS |
GO:0046942 carboxylic acid transport | * | * | * | NS |
GO:0005975 carbohydrate metabolism | ** | *** | ** | *** |
GO:0044262 cellular carbohydrate metabolism | *** | *** | * | ** |
GO:0016052 carbohydrate catabolism | ** | ** | * | NS |
GO:0044275 cellular carbohydrate catabolism | ** | ** | * | NS |
   GO:0003674 molecular function |  |  |  |  |
GO:0016491 oxidoreductase activity | *** | *** | *** | *** |
GO:0016705 oxidoreductase activity with incorporation or reduction of molecular oxygen | * | ** | NS | * |
Up-regulated Interpro categories | Â | Â | Â | Â |
   IPR000073 Alpha-beta hydrolase fold | * | * | NS | * |
   IPR001128 Cytochrome P450 | *** | *** | * | NS |
   IPR002198 Short-chain dehydrogenase/reductase SDR | ** | *** | NS | ** |
   IPR002347 Glucose-ribitol dehydrogenase | *** | *** | NS | *** |
   IPR004045 Glutathione-S-transferase N-terminal | ** | *** | *** | *** |
   IPR004046 Glutathione-S-transferase C-terminal | ** | *** | *** | *** |
Down-regulated Gene Ontology categories | Â | Â | Â | Â |
   GO:0008150 biological process |  |  |  |  |
GO:0009059 macromolecular biosynthesis | * | *** | ** | * |
GO:0006412 protein biosynthesis | ** | *** | *** | ** |
GO:0043037 translation | * | *** | * | NS |
GO:0046907 intracellular transport | *** | * | NS | * |
GO:0006605 protein targeting | ** | ** | ** | NS |
GO:0006996 organelle organization and biogenesis | ** | *** | NS | * |
GO:0007010 cytoskeleton organization/biogenesis | * | *** | NS | * |
GO:0007017 microtubule-based process | ** | * | NS | * |
GO:0009790 embryonic development | *** | *** | NS | * |
GO:0043283 biopolymer metabolism | *** | *** | NS | * |
   GO:0003674 molecular function |  |  |  |  |
GO:0005488 binding | *** | *** | NS | * |
GO:0003676 nucleic acid binding | * | *** | NS | * |
GO:0008135 translation factor, nucleic acid binding | * | *** | NS | ** |
GO:0045182 translation regulator activity | * | *** | NS | ** |
Down-regulated Interpro categories | Â | Â | Â | Â |
   IPR000980 SH2 motif | *** | *** | * | NS |
   IPR002111 Cation not K+ channel TM region | * | * | NS | * |