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Table 3 Examples of significantly enriched GO annotation for the list of morphine-responsive genes

From: Morphine effects on striatal transcriptome in mice

Mouse strain Morphine treatment mRNA change Enriched GO annotation (GO ID) Number of genes P Example genes
C57BL/6J Acute +a Regulation of apoptosis (0042981) 11 9.1 × e-06b Tsc22d3, Pmaip1, and Plekhf1
129P3/J Chronic - Nucleosome assembly (0006334) 5 1.7 × e-04 Hist1h1c, Hist1h3b, and Hist1h2bl
C57BL/6J Chronic - Transmission of nerve impulse (0019226) 10 8.6 × e-04 Sncaip, Adora2a, and Npy5r
DBA/2J Acute + Response to abiotic stimulus (0009628) 15 9.8 × e-04 Cryab, Dnajb1, and Cdkn1a
DBA/2J Acute + Response to temperature stimulus (0009266) 5 1.7 × e-03 Hspa8, Hspa1b, and Cryab
C57BL/6J Chronic - Cellular lipid metabolism (0044255) 17 1.95 × e-04 Vldr, Sc5d, and Acsl3
SWR/J Acute + Glucose transport (0015758) 4 2.0 × e-03 Stxbp3a, Stxbp4, and Aps
SWR/J Chronic - Cell communications (0007154) 25 2.3 × e-03 Plcd4, Gjb1, and Utrn
129P3/J Acute - Neuron differentiation (0030182) 5 2.4 × e-03 Olig2, Gli3, and Ablim1
SWR/J Acute + Carboxylic acid metabolism (0019752) 16 1.4 × e-03 Cpt1a, Cpt2, and Crot
C57BL/6J Chronic + Negative regulation of biological process (0048519) 12 7.5 × e-03 Zbtb16, Sgk3, and Adrb1
SWR/J Acute - Nervous system development (0007399) 7 9.9 × e-03 Olig2, Rgma, and Ugt8a
129P3/J Chronic + Intracellular signaling cascade (0007242) 12 1.0 × e-02 Ppm1, Dab1, and Snx24
  1. The complete results of the Gene Ontology (GO) analysis are presented in Additional data file 3. a(+) increased mRNA abundance in response to morphine; (-) decreased mRNA level. bStatistical significance of functional over-representation was computed using Fisher's exact test.