Table 3 Examples of significantly enriched GO annotation for the list of morphine-responsive genes

C57BL/6J

Acute

+^a

Regulation of apoptosis (0042981)

11

9.1 × e^-06b

Tsc22d3, Pmaip1, and Plekhf1

129P3/J

Chronic

-

Nucleosome assembly (0006334)

5

1.7 × e^-04

Hist1h1c, Hist1h3b, and Hist1h2bl

C57BL/6J

Chronic

-

Transmission of nerve impulse (0019226)

10

8.6 × e^-04

Sncaip, Adora2a, and Npy5r

DBA/2J

Acute

+

Response to abiotic stimulus (0009628)

15

9.8 × e^-04

Cryab, Dnajb1, and Cdkn1a

DBA/2J

Acute

+

Response to temperature stimulus (0009266)

5

1.7 × e^-03

Hspa8, Hspa1b, and Cryab

C57BL/6J

Chronic

-

Cellular lipid metabolism (0044255)

17

1.95 × e^-04

Vldr, Sc5d, and Acsl3

SWR/J

Acute

+

Glucose transport (0015758)

4

2.0 × e^-03

Stxbp3a, Stxbp4, and Aps

SWR/J

Chronic

-

Cell communications (0007154)

25

2.3 × e^-03

Plcd4, Gjb1, and Utrn

129P3/J

Acute

-

Neuron differentiation (0030182)

5

2.4 × e^-03

Olig2, Gli3, and Ablim1

SWR/J

Acute

+

Carboxylic acid metabolism (0019752)

16

1.4 × e^-03

Cpt1a, Cpt2, and Crot

C57BL/6J

Chronic

+

Negative regulation of biological process (0048519)

12

7.5 × e^-03

Zbtb16, Sgk3, and Adrb1

SWR/J

Acute

-

Nervous system development (0007399)

7

9.9 × e^-03

Olig2, Rgma, and Ugt8a

129P3/J

Chronic

+

Intracellular signaling cascade (0007242)

12

1.0 × e^-02

Ppm1, Dab1, and Snx24