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Table 3 Examples of significantly enriched GO annotation for the list of morphine-responsive genes
| Mouse strain | Morphine treatment | mRNA change | Enriched GO annotation (GO ID) | Number of genes | P | Example genes |
|---|---|---|---|---|---|---|
| C57BL/6J | Acute | +a | Regulation of apoptosis (0042981) | 11 | 9.1 × e-06b | Tsc22d3, Pmaip1, and Plekhf1 |
| 129P3/J | Chronic | - | Nucleosome assembly (0006334) | 5 | 1.7 × e-04 | Hist1h1c, Hist1h3b, and Hist1h2bl |
| C57BL/6J | Chronic | - | Transmission of nerve impulse (0019226) | 10 | 8.6 × e-04 | Sncaip, Adora2a, and Npy5r |
| DBA/2J | Acute | + | Response to abiotic stimulus (0009628) | 15 | 9.8 × e-04 | Cryab, Dnajb1, and Cdkn1a |
| DBA/2J | Acute | + | Response to temperature stimulus (0009266) | 5 | 1.7 × e-03 | Hspa8, Hspa1b, and Cryab |
| C57BL/6J | Chronic | - | Cellular lipid metabolism (0044255) | 17 | 1.95 × e-04 | Vldr, Sc5d, and Acsl3 |
| SWR/J | Acute | + | Glucose transport (0015758) | 4 | 2.0 × e-03 | Stxbp3a, Stxbp4, and Aps |
| SWR/J | Chronic | - | Cell communications (0007154) | 25 | 2.3 × e-03 | Plcd4, Gjb1, and Utrn |
| 129P3/J | Acute | - | Neuron differentiation (0030182) | 5 | 2.4 × e-03 | Olig2, Gli3, and Ablim1 |
| SWR/J | Acute | + | Carboxylic acid metabolism (0019752) | 16 | 1.4 × e-03 | Cpt1a, Cpt2, and Crot |
| C57BL/6J | Chronic | + | Negative regulation of biological process (0048519) | 12 | 7.5 × e-03 | Zbtb16, Sgk3, and Adrb1 |
| SWR/J | Acute | - | Nervous system development (0007399) | 7 | 9.9 × e-03 | Olig2, Rgma, and Ugt8a |
| 129P3/J | Chronic | + | Intracellular signaling cascade (0007242) | 12 | 1.0 × e-02 | Ppm1, Dab1, and Snx24 |
