Table 1 List of genes with CNS tissue-specific AS regulation
From: Functional coordination of alternative splicing in the mammalian central nervous system
Category | Gene name | Accession | CNS function/phenotype |
|---|---|---|---|
Signaling | Arhgef7 | AF247655 | Synapse formation |
| Â | Camk2d | BC042895 | Phosphorylates PSD-95 in postsynaptic density |
| Â | Camk2g | BU560927 | Phosphorylates PSD-95 in postsynaptic density |
| Â | Git2 | BU614137 | Postsynaptic density interactions |
| Â | Map4k6 | BC011346 | Axon guidance |
| Â | Map3k4 | AK122219 | Neural tube development |
| Â | Opa1 | AK050383 | Neuropathy |
| Â | Plcb4 | BC051068 | Metabotropic glutamate neurotransmitter signaling pathway, synaptic depression |
| Â | Ptprf | AF300943 | Synapse formation |
| Â | Ptprk | L10106 | Neurite outgrowth |
| Â | Rapgef6 | BC019702 | Neurogenesis, gliogenesis |
| Â | Rap1ga1 | BY234371 | Neurite outgrowth |
| Â | Vav2 | U37017 | Neurite outgrowth |
Cytoskeleton | Ablim1 | AK122196 | Axon guidance |
| Â | Clasp1 | CA326660 | Axon guidance |
| Â | Dst | AK037206 | Neurodegeneration, myelination, retrograde axonal transport |
| Â | Kifap3 | D50367 | Axonal vesicle transport |
| Â | Myo5a | CA469310 | Synaptic vesicle transport |
| Â | Myo6 | U49739 | Neurotransmitter endocytosis |
| Â | Syne1 | BC041779 | Synaptic nuclear envelope anchor at neuromuscular junction |
| Â | Tmod2 | AU035865 | Learning/memory, long-term potentiation |
Vesicular transport | Dlgh4 | D50621 | Synaptic vesicle maturation |
| Â | Dnm1 | BC034679 | Synaptic vesicle endocytosis |
| Â | Exoc7 | AF014461 | Neurotransmitter receptor membrane targeting |
| Â | Rab6ip2 | AF340029 | Neurotransmitter release |
| Â | Snap23 | AA450833 | Neurotransmitter exocytosis |
| Â | Sgip1 | BC017596 | Neural energy balance regulation |
| Â | Syngr1 | AK010442 | Synaptic vesicle component |
mRNA processing | Adarb1 | AF525421 | Glutamate receptor mRNA editing |
| Â | Papola | NM_011112 | Regulated polyadenylation at synapses |
Transcription factors | Apbb1 | BM950527 | Learning/memory, Alzheimer's disease |
| Â | Nfatc3 | BC021835 | Axon outgrowth, neuronal survival, astrocyte function |
| Â | Tcf12 | X64840 | Transcription factor involved in neuronal plasticity, CNS development |
Tight junctions | Baiap1 | AK032350 | Nervous system signaling |
| Â | Magi3/6530407C02Rik | AF213258 | CNS signaling, neurotransmitter receptor regulation |
| Â | Tjp4 | BU612515 | Interacts with synaptic protein |
Ion channels | P2rx4 | AF089751 | Neurotransmitter receptor |
| Â | Slc24a2 | NM_172426 | Calcium ion channel in axon terminals |
Other functions | Agrn | BG803812 | Regulates formation of postsynaptic structure at the neuromuscular junction |
| Â | Kidins220/C330002I19Rik | AK083260 | Neural signaling |
| Â | Mgea6 | BI962144 | Meningioma antigen |
| Â | Mgrn1 | BY567496 | Neuronal degradation, astrocytosis |
| Â | Neo1 | Y09535 | Axon guidance, neuronal survival |
| Â | NIBP/1810044A24Rik | BC034590 | Neurite outgrowth, nerve growth factor signaling |
| Â | Pcmt1 | AA981003 | Memory, synaptic function, seizures |
| Â | Sca2 | AF041472 | Neurodegenerative disease spinocerebellar ataxia |
| Â | Serpinh1 | BB613516 | Glial cell protection, CNS development |