Table 2 Significant pathways for TGF-β gene signatures
Pathway | TFs | Significant TFs | P value |
|---|---|---|---|
Yang et al. gene signature | |||
AhR | AhR, ER-α, Sp1, p300, NF-κB, Arnt | AhR, Sp1, p300, NF-κB, Arnt | <0.001 |
EGF | c-Fos, Elk-1, Sp1, STAT3, c-Jun, STAT1α, c-Myc | Sp1, c-Jun, c-Myc | <0.001 |
c-Kit | MITF, Sp1, Tal-1, p300, GATA-1 | Sp1, p300 | <0.001 |
p53 | TFIIA, E2F1, p53, p300, BRCA1, YY1 | E2F1, p53, p300, BRCA1 | <0.001 |
Caspases | CREB, Max, SRF, p53, AP-2α | CREB, Max, p53, AP-2α | <0.001 |
MAPK | CREB, Elk-1, p53, c-Jun, c-Myc | CREB, p53, c-Jun, c-Myc | <0.001 |
E2F | DP-1, E2F, p53 | DP-1, E2F, p53 | <0.001 |
HIF-1 | p53, p300, HIF-1α, HNF-4α2, Arnt | p53, p300, HIF-1α, Arnt | <0.001 |
Stress | PPAR-γ, c-Ets-1, PPAR-α, Max NF-AT2, HSF1, c-Jun, Elk-1, p53, CHOP-10, CREB, CRE-BP2, RXR-α, HNF-1α, STAT3, MRF4 | Max, c-Jun, p53, CREB, CRE-BP2, RXR-α | 0.001 |
TLR3 | CRE-BP2, p300, c-Jun, IRF-3, IRF-7, NF-κB | CRE-BP2, p300, c-Jun, NF-κB | 0.002 |
TLR4 | CREB, CRE-BP2, STAT1, Elk-1, p300, IRF-3, IRF-7, NF-κB | CREB, CRE-BP2, p300, NF-κB | 0.002 |
p38 | ELk-1, p53, MITF, PPAR-α, CHOP-10, Max, CREB, PU.1, HNF-1α, CRE-BP2, NF-AT2, STAT3, MRF4 | p53, Max, CREB, CRE-BP2 | 0.003 |
JNK | CRE-BP2, p53, HSF1, PPAR-γ, STAT3, c-Jun, c-Ets-1 | CRE-BP2, p53, c-Jun | 0.004 |
TGF-β | LEF-1, CRE-BP2, Smad2, Smad3, Smad4 | CRE-BP2, Smad4 | 0.006 |
EDAR | c-Jun, NF-κB | c-Jun, NF-κB | 0.015 |
IL-1 | ELk-1, c-Jun, NF-κB | c-Jun, NF-κB | 0.015 |
TCR2 | c-Jun, NF-κB, NF-AT | c-Jun, NF-κB | 0.018 |
RANK | MITF, PU.1, c-Jun, NF-κB | c-Jun, NF-κB | 0.020 |
Hypoxia | ER-α, p53, AP-1, HIF-1α | p53, HIF-1α | 0.033 |
Notch | Max, LEF-1, p300, c-Myc | Max, p300, c-Myc | 0.037 |
Karlsson et al . gene signature | |||
AhR | AhR, ER-α, Sp1, p300, NF-κB, Arnt | AhR, Sp1, Arnt | <0.001 |
EGF | c-Fos, Elk-1, Sp1, STAT3, c-Jun, STAT1α, c-Myc | Sp1, STAT1α, c-Myc | <0.001 |
c-Kit | MITF, Sp1, Tal-1, p300, GATA-1 | Sp1, Tal-1 | <0.001 |
p53 | TFIIA, E2F1, p53, p300, BRCA1, YY1 | E2F1, BRCA1 | <0.001 |
Caspases | CREB, Max, SRF, p53, AP-2α | Max, AP-2α | <0.001 |
E2F | DP-1, E2F, p53 | DP-1, E2F | 0.002 |
HIF-1 | p53, p300, HIF-1α, HNF-4α2, Arnt | HIF-1α, Arnt | 0.006 |
Notch | Max, LEF-1, p300, c-Myc | Max, c-Myc | 0.019 |