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Table 3 Phenotypes of deletions of integrin subunits in the mouse

From: The integrins

Integrin subunit Viability Fertility Phenotype Reference
α1 + + Defects in bone healing and reduced tumor angiogenesis [36]
α2 + + Reduced branching morphogenesis and platelet adhesion [37]
α3 Perinatal lethal + Kidney, lung, and skin defects [38]
α4 Embryonic lethal - Placental and heart defects [39]
α5 Embryonic lethal - Mesodermal and vascular defects [40]
α6 Perinatal lethal + Epidermal detachment, defect in neurogenesis [41]
α7 + + Muscular dystrophy [42]
α8 Perinatal lethal + Kidney defect [43]
α9 Perinatal lethal + Chylothorax (defect in lymphatic drainage) [44]
αv Embryonic and perinatal lethal + Cerebral hemorrhage [45]
αM + + Neutrophil adhesion and degranulation [46]
αL + + Neutrophil emigration [47]
αD + + Reduced T-cell response and T-cell phenotypic changes [48]
αE + + Skin inflammation [49]
β1 Embryonic lethal - Fails to gastrulate [45,50]
β2 + + Leukocyte adhesion deficiency [51]
β3 + + Platelet defect [52]
β4 Perinatal lethal + Epidermal detachment [53]
β5 + + Accelerated age-related blindness [54]
β6 + + Inflammation in skin and lungs [55]
β7 + + Gut-associated lymphocyte defects [56]
β8 Embryonic and perinatal lethal + Cerebral hemorrhage [57]