From: The integrins
Integrin subunit | Viability | Fertility | Phenotype | Reference |
---|---|---|---|---|
α1 | + | + | Defects in bone healing and reduced tumor angiogenesis | [36] |
α2 | + | + | Reduced branching morphogenesis and platelet adhesion | [37] |
α3 | Perinatal lethal | + | Kidney, lung, and skin defects | [38] |
α4 | Embryonic lethal | - | Placental and heart defects | [39] |
α5 | Embryonic lethal | - | Mesodermal and vascular defects | [40] |
α6 | Perinatal lethal | + | Epidermal detachment, defect in neurogenesis | [41] |
α7 | + | + | Muscular dystrophy | [42] |
α8 | Perinatal lethal | + | Kidney defect | [43] |
α9 | Perinatal lethal | + | Chylothorax (defect in lymphatic drainage) | [44] |
αv | Embryonic and perinatal lethal | + | Cerebral hemorrhage | [45] |
αM | + | + | Neutrophil adhesion and degranulation | [46] |
αL | + | + | Neutrophil emigration | [47] |
αD | + | + | Reduced T-cell response and T-cell phenotypic changes | [48] |
αE | + | + | Skin inflammation | [49] |
β1 | Embryonic lethal | - | Fails to gastrulate | [45,50] |
β2 | + | + | Leukocyte adhesion deficiency | [51] |
β3 | + | + | Platelet defect | [52] |
β4 | Perinatal lethal | + | Epidermal detachment | [53] |
β5 | + | + | Accelerated age-related blindness | [54] |
β6 | + | + | Inflammation in skin and lungs | [55] |
β7 | + | + | Gut-associated lymphocyte defects | [56] |
β8 | Embryonic and perinatal lethal | + | Cerebral hemorrhage | [57] |