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Table 1 Significance values relating genomic properties to clusters defined by the TBP regulatory network*

From: A TATA binding protein regulatory network that governs transcription complex assembly

  

Cluster number†

Row‡

Property

0

1

2

3

4

5

6

7

8

9

 

Environmental stress

          

1

Induced during heat stress

-25

-6

...

8

...

30

35

...

...

...

2

Repressed during heat stress

-7

106

...

...

...

...

...

...

...

...

 

Gene ontology §

          

3

RB genes¶

...

69

...

...

...

...

...

...

...

...

4

RP genes¶

...

...

...

...

-4

...

...

...

31

14

5

Oxidative phosphorylation {GO:6119}

...

...

...

...

...

...

...

...

...

13

6

Amine metabolism {GO:9308}

...

...

...

8

...

...

...

...

...

...

7

Alcohol metabolism {GO:6066}

...

...

...

5

...

9

4

...

...

...

8

Energy derivation {GO:15980}

...

...

...

...

...

6

13

...

...

5

9

Sporulation {GO:30435}

...

...

...

...

4

...

...

...

...

...

10

Ty element transposition {GO:6319}

...

...

...

...

...

...

...

6

...

...

11

Proteolysis {GO:6508}

...

...

6

...

...

...

...

...

...

...

 

General properties

          

12

Lowly transcribed

84

...

...

...

89

...

...

10

...

...

13

Highly transcribed

...

...

...

...

-7

...

...

...

12

21

14

Low mRNA levels

14

...

...

...

28

-5

-6

...

...

...

15

High mRNA levels

-7

-6

...

...

-7

...

32

...

8

21

16

SAGA-dominated

-46

...

...

9

...

53

43

...

...

...

17

TATA-containing

-52

-6

...

9

12

45

46

...

...

4

18

Low H3 K4Me2 in ORF

...

...

...

...

58

...

...

...

...

...

19

Low H3 K4Me2 in IGR

...

...

...

...

28

...

...

...

...

...

 

Positively regulated by

          

20

Spt3 (SAGA)

-31

-4

-7

...

28

5

31

28

...

...

21

Mot1

...

...

...

...

-4

-6

...

...

27

8

22

Bur6 (NC2)

13

15

...

...

...

-5

...

...

17

...

23

Bdf1 (TFIID)

11

...

...

...

...

...

...

10

6

...

24

Bdf2

...

...

...

...

20

...

...

...

...

...

25

TAF1 (TFIID)

...

...

...

...

...

...

...

...

10

5

 

Negatively regulated by

          

26

RP genes

...

Â¥

...

...

...

...

...

...

...

...

27

Spt3 (SAGA)

-8

6

27

30

...

...

...

-5

...

...

28

Mot1

-25

...

...

15

22

36

5

...

-6

...

29

Bur6 (NC2)

-28

...

...

5

13

43

9

...

-4

...

30

Bdf1 (TFIID)

-21

...

...

10

...

25

8

...

...

...

31

Hda1

-23

...

...

...

25

11

5

5

...

...

32

Tup1 (SSN6-TUP1)

-31

...

-4

...

52

12

11

17

...

...

33

Set1 (COMPASS)

-8

...

-6

...

60

...

...

15

...

...

  1. *Values represent -log10 p values, using the extreme most 10% of the data points (n > approximately 3,000) as identified in Additional data file 4, and are calculated using the CHITEST formula in EXCEL. Negative signs are inserted where relationships are anti-correlated. For clarity, any absolute value less than 4 was replaced with a period. †Cluster numbers refer to clusters shown in Figure 3. Cluster 0 includes all genes not clustered in Figure 3. ‡Row identifier in the text. References are provided in Additional data file 4. §Gene Ontology term identifier is provided in brackets. P values were derived using 'GO term finder' [62]. ¶RP genes are defined here as genes defined by the following Gene Ontology terms: ribosomal protein, mitochondrial ribosomal protein, translational elongation, translational initiation, translational termination, protein biosynthesis. RB genes are defined here by the following Gene Ontology terms: 35S primary transcript processing, ribosomal large subunit assembly and maintenance, rRNA metabolism, rRNA modification, rRNA processing, rRNA nucleus export, transcription from Pol I promoter, tRNA methylation, tRNA modification, tRNA processing, tRNA splicing, tRNA nucleus export, regulation of translation, processing of 20S pre-rRNA. ¥Up-regulated upon deletion of RPL12A (p < 10-24), RPL27A (p < 10-26), RPL34A (p < 10-8), RPL6B (p < 10-9), RPL8A (p < 10-63), or RPL24A (p < 10-20); see entries R135T, R137T, R138T, R139T, R140T, R141T in Additional data file 4.