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Table 1 Interaction partners of Homer family proteins

From: The Homer family proteins

Protein Species Binding sequence or domain Amino acids Binding domain of Homer References
mGluR1a Rat Pro-Pro-Ser-Pro-Phe 1146-1150 EVH1 [1,5,6]
mGluR15 Rat Pro-Pro-Ser-Pro-Phe 1124-1128 EVH1 [1,5,6]
IP3 receptor type1 Human Pro-Pro-Lys-Lys-Phe 49-53 EVH1 [43]
IP3 receptor type3 Human Pro-Pro-Lys-Lys-Phe 48-52 EVH1 [43]
Actin Mouse ND ND EVH1 [7]
Shank1 Rat Pro-Pro-Lys-Glu-Phe 1566-1570 EVH1 [64]
Shank3 Rat Pro-Pro-Glu-Glu-Phe 1310-1314 EVH1 [64]
RyR1 Human Pro-Pro-His-His-Phe 1772-1776 EVH1 [43]
TRPC1 Human Pro-Pro-Pro-Phe 645-649 EVH1 [65]
PIKE-L Rat Pro-Lys-Pro-Phe 187-191 EVH1 [50]
DynaminIII Human Pro-Pro-Val-Pro-Phe 799-803 EVH1 [43,66]
Oligophrenin-1 Human Pro-Pro-Leu-Glu-Phe 4-8 EVH1 [62]
synArfGEF Rat   874-981 EVH1 [67]
DrebrinE Mouse Pro-Pro-Ala-Thr-Phe 546-550 EVH1 [27]
  Mouse Pro-Pro-Pro-Val-Phe 628-632 EVH1 [27]
Oskar Drosophila ND ND EVH1 [57]
C/EBPb Human Pro-Pro-Pro-Ara-Phe 16-20 EVH1 [68]
Pax6 Human Carboxy-terminal Pro-Ser-Thr-rich domain ND Homer3 lacking N-terminal 70 amino acids [69]
Syntaxin-13 Mouse Carboxy-terminal 153 amino acids 1-153 Homer1b carboxy-terminal 190 amino acids [21]
Homer1b/c Mouse Carboxy-terminal CC 175-366 Carboxy-terminal CC [5,6,20]
Homer1b/c Mouse LZ 289-323, 335-363 Homer1b/c LZ [8,16]
Homer1b/c Mouse Ser-Pro-Leu-Thr-Pro (P motif) 138-142 EVH1 [19]
Homer2 Mouse Carboxy-terminal CC 112-354 Carboxy-terminal CC [6,8]
Homer3 Mouse Carboxy-terminal CC 102-358 Carboxy-terminal CC [8]
Activated Cdc42 Human ND ND Homer2 CC [7]
  1. Abbreviations: CC, coiled-coil; C/EBP, CCAAT/enhancer binding protein; IP3, inositol 1,4,5-trisphosphate; LZ, leucine zipper; mGluR, metabotropic glutamate receptor; PIKE-L, phosphoinositide 3 kinase enhancer; RyR, ryanodine receptor; synArfGEF, guanine-nucleotide exchange factor for ADP-ribosylation factor; TRPC, transient receptor potential channel