Longevity promoting genes conserved between C. elegans daf-2 mutants and MnSOD over-expressing Drosophila. Drosophila and C. elegans ortholog matches that are differentially expressed in response to MnSOD over-expression (both time points) and in daf-2 mutants in a daf-16 dependent manner. Expected values from BLASTP are indicated as follows: *5 × 10-10 <p ≤ 5 × 10-02, **5 × 10-70 <p ≤ 5 × 10-10, *** p ≤ 5 × 10-70. Beige shading indicates genes that are not reciprocal best BLAST hits, but are members of the corresponding gene family. Orange or blue text indicates genes that are up-regulated or down-regulated during normal Drosophila aging, respectively. AIRS, 5' phosphoribosyl-5-aminoimidazole synthetase; AIRC, 5'-phosphoribosyl-5-aminoimadizole carboxylase; AICAR, 5'-phosphoribosyl-4-carboxamide-5 aminoimadizole carboxylase; FGARAT, 5'-phosphoribosyl-N-formylglycinamide amidotransferase; GARS, 5'-phosphoribosylglycinamide synthetase; GART, 5'-phosphoribosylglycinamide transformylase; SAICAR, 5' phosphoribosyl-4-(N-succinocarboxaminde)-5 amidoimidazole synthetase.