From: Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
Gene name | Chromosomal band | Description | GO term |
---|---|---|---|
Module A | |||
DNAJC14 | [12q13.2] | Nuclear protein Hcc-1 (Proliferation associated cytokine-inducible protein CIP29) | Heat shock protein binding, unfolded protein binding |
HNRPLL | [2p22.1] | Heterogeneous nuclear ribonucleoprotein L-like (Stromal RNA-regulating factor) | Nucleotide binding, RNA binding, mRNA processing |
BAT1 | [6p21.33] | Spliceosome RNA helicase BAT1 (HLA-B associated transcript-1) | Nucleotide binding, nucleic acid binding, ATP-dependent RNA helicase activity, nuclear mRNA splicing, mRNA export from nucleus, ATP biosynthetic process, ion transport |
ITPR3 | [6p21.31] | Inositol 1,4,5-trisphosphate receptor type 3 | Ion channel activity, calcium channel activity, calcium ion transport, protein binding, signal transduction |
RPS18 | [6p21.32] | 40S ribosomal protein S18 (Ke-3) | RNA binding, structural constituent of ribosome, rRNA binding, translation |
TUBB | [6p21.33] | Tubulin beta-2 chain | Nucleotide binding, GTPase activity, cell motility, natural killer cell mediated cytotoxicity |
LMO7 | [13q22.2] | LIM domain only protein 7 (LOMP) (F-box only protein 20) | Protein ubiquination, actomyosin structure and biogenesis, protein binding, ion binding |
WDR1 | [4p16.1] | WD repeat domain 1 (WDR1), transcript variant 1 | Actin binding, protein binding, sensory perception of sound |
RPS15A | [16p12.3] | 40S ribosomal protein S15a | Protein binding, structural constituent of ribosome, translation |
ELF5 | [11p13] | ETS-related transcription factor Elf-5 (E74-like factor 5) | Transcription factor activity, sequence-specific DNA binding, regulation of transcription, cell proliferation |
Module B | |||
RDBP | [6p21.3] | RD RNA-binding protein, MHC complex gene RD | RNA binding, nucleotide binding, transcription, regulation of transcription |
GTF2H | [2q14.3] | Basic transcription factor 2 89 kDa subunit, DNA excision repair protein ERCC-3 | DNA binding, ATP-dependent DNA helicase activity, transcription-coupled nucleotide-excision repair, regulation of transcription |
RRN3 | [16p13.11] | RNA polymerase I-specific transcription initiation factor | RNA polymerase I transcription factor activity, regulation of transcription |
ERCC4 | [16p13.12] | DNA excision repair protein, DNA repair endonuclease | DNA binding, magnesium ion binding, nucleotide excision repair |
TAF1A | [1q41] | TATA box binding protein (TBP)-associated factor, RNA polymerase I | DNA binding, RNA polymerase I transcription factor activity, regulation of transcription |
TYW3 | [1p31.1] | tRNA-yW synthesizing protein 3 homolog | None |
GUF1 | [4p13] | GTP-binding protein GUF1 homolog, GTPase of unknown function | Nucleotide binding, translation initiation factor activity, GTPase activity, small GTPase mediated activity |
Module C | |||
MOG | [6p22.1] | Myelin-oligodendrocyte glycoprotein precursor | Synaptic transmission, central nervous system development |
APLP2 | [11q24.3] | Amyloid-like protein 2 precursor (APPH) | DNA binding, protein binding, G-protein coupled receptor protein signaling pathway |
NTRI | [11q25] | Neurotrimin precursor (hNT) | Protein binding, cell adhesion, neuron recognition |
Module D | |||
DDX52 | [17q12] | Probable ATP-dependent RNA helicase DDX52 (DEAD box protein 52) | Nucleotide binding, ATP binding, ATP-dependent helicase activity |
RPL23A | [17q11.2] | 60S ribosomal protein L23a | Nucleotide binding, rRNA binding, translation |
NPM1 | [5q35.1] | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) | Transcription coactivator activity, RNA binding, intracellular protein transport, anti-apoptosis, response to stress |
RPL26L1 | [5q35.1] | 60S ribosomal protein L26-like 1 | Structural constituent of ribosome, translation |
PRDX1 | [1p34.1] | Natural killer cell-enhancing factor A, Peroxiredoxin-1 | Oxidoreductase activity, peroxiredoxin, cell proliferation |
RPS7 | [2p25.3] | 40S ribosomal protein S7 | RNA binding, protein binding, translation |
NGB | [14q24.3] | Neuroglobin | Oxygen transporter activity, metal ion binding |
FLOT1 | [6p21.33] | Flotillin 1, integral membrane component of caveolae | Protein binding |
SESN1 | [6q21] | Sestrin-1 (p53-regulated protein PA26) | Response to DNA damage stimulus, cell cycle arrest, negative regulation of cell proliferation |
SESN2 | [1p35.3] | Sestrin-2, hypoxia induced gene 95 (Hi95) | Cell cycle arrest |