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Table 3 Gene ontologies of up-regulated processes in BCs versus epithelial cells

From: GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silicodissection of mixed phenotypes

Gene category

List hits

EASE score

Response to external stimulus (lymphocytic)

146

5.14E-09

Cellular process

490

4.74E-06

Response to biotic stimulus (lymphocytic)

94

4.87E-06

Ion transport

68

7.05E-06

Defense response (lymphocytic)

87

1.09E-05

Development (developmental)

165

5.05E-05

Hemostasis

19

1.15E-04

Blood coagulation (coagulation)

18

1.68E-04

Cell-cell signaling

60

2.23E-04

Response to abiotic stimulus (lymphocytic)

60

3.74E-04

Cyclic-nucleotide-mediated signaling

19

3.92E-04

Morphogenesis (developmental)

101

4.23E-04

Response to light

26

5.54E-04

Natural killer cell activation (lymphocytic)

6

7.08E-04

Second-messenger-mediated signaling

20

8.47E-04

Perception of light

25

9.29E-04

Synaptic transmission (neurophysiology)

31

9.63E-04

Cell communication

244

1.07E-03

Cation transport

46

1.46E-03

Transmission of nerve impulse (neurophysiology)

31

1.61E-03

Transport

159

1.65E-03

Response to radiation

26

1.73E-03

Organogenesis (developmental)

88

2.09E-03

Metal ion transport

36

2.15E-03

Perception of abiotic stimulus (lymphocytic)

35

2.34E-03

Vision

23

2.54E-03

Immune response (lymphocytic)

68

3.77E-03

Perception of external stimulus (lymphocytic)

37

4.60E-03

Cell surface receptor linked signal transduction

93

5.44E-03

Xenobiotic metabolism

10

6.19E-03

Sensory perception

34

6.34E-03

Heme biosynthesis (erythrocytic)

5

6.40E-03

Response to xenobiotic stimulus

10

8.00E-03

Skeletal development (development)

18

8.65E-03

Potassium ion transport

19

8.71E-03

G-protein signaling

15

9.32E-03

Pigment biosynthesis (erythrocytic)

6

1.10E-02

Monovalent inorganic cation transport

29

1.15E-02

Heme metabolism (erythrocytic)

5

1.16E-02

Negative regulation of natural killer cell activity (lymphocytic)

3

1.28E-02

Regulation of natural killer cell activity (lymphocytic)

3

1.28E-02

Anion transport

15

1.49E-02

Heart development (heart development)

6

1.63E-02

Histogenesis (developmental)

16

1.85E-02

Porphyrin biosynthesis (erythrocytic)

5

1.90E-02

Pigment metabolism (erythrocytic)

6

1.95E-02

Pigmentation (erythrocytic)

6

2.30E-02

Mesoderm development (mesoderm development)

7

2.37E-02

Cellular defense response (lymphocytic)

13

2.44E-02

Response to pest/pathogen/parasite (lymphocytic)

43

2.63E-02

  1. When genes were clustered based on their GO, we identified processes characteristic of lymphocytic cells (response to stimulus, defense response, immune response), erythrocytes (heme and porphyrin biosynthesis), coagulation, neurophysiology, development, and mesoderm and heart development.