Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Table 1 Differentially over-represented biological function GO categories between resistant (R) and sensitive (S) lines

R > S	S > R
Response to abiotic stimulus 1.80E-06*	Alcohol metabolism 4.00E-03
Response to chemical stimulus 1.26E-06	Response to toxin 2.90E-02
Response to toxin 4.19E-07	Response to biotic stimulus 4.32E-05
Response to pheromone 2.10E-08	Defense response 2.13E-05
Chemosensory behavior 8.00E-04	Immune response 1.00E-04
Extracellular transport 2.07E-08	Electron transport 2.88E-05
Lipid metabolism 8.0E-05	Lipid metabolism 2.99E-09
Cellular lipid metabolism 1.20E-04	Cellular lipid metabolism 1.29E-11
Phospholipid metabolism 2.30E-03	Organic acid metabolism 2.37E-07
Steroid metabolism 2.00E-05	Steroid metabolism 9.80E-4
	Fatty acid metabolism 1.56E-10
	Catabolism 1.53E-05
	Cellular catabolism 1.08E-06
	Carbohydrate metabolism 5.20E-05

*p values were calculated from χ² tests, estimating which categories were represented more frequently than expected by chance, based on their representation on the microarray.

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