Simplified ontologies allowing comparison of developmental mammalian gene expression

Table 1 Statistics of the individual developmental eVOC ontologies, representing the alignment between human and mouse stages

Theiler stage	Mouse terms	External reference	Carnegie stage	Human terms	External reference
1	6	4	1	5	4
2	5	3	2	5	4
3	6	4
4	12	9	3	13	11
5	9	6
6	10	7	4	10	8
7	11	9
8	12	10	5a	10	8
			5b	11	10
			5c	9	8
9	14	14	6a	14	16
			6b	19	18
10	14	18	7	20	17
11	32	29	8	22	19
12	56	63	9	52	54
13	55	64	10	60	80
14	67	85	11	72	92
15	80	109	12	80	98
16	93	128	13	103	131
17	103	137	14	122	149
18	116	155	15	131	165
19	134	173	16	155	178
20	157	171	17	170	184
21	193	239	18	188	223
			19	199	237
22	209	299	20	200	237
23	216	303
24	226	316
25	234	339
26	238	348
27	266	0
28	266	246	Adult	512
Total	2,840	3,288		2,049	1,951

The first three columns display the individual mouse ontologies, the number of terms in each ontology, and the number of external references of each. The last three columns display the individual human ontologies, the number of terms, and the number of external references of each. The external references refer to the EMAP and MA ontologies for mouse, and to HUMAT for human. The alignment of the rows between the mouse and human ontologies represents the alignment of the Theiler and Carnegie stages of development based on morphological similarities. For example, the Theiler Stage 4 ontology contains 12 terms and has 9 mappings to the EMAP ontology. Mouse Theiler Stage 4 is equivalent to human Carnegie Stage 3. The Carnegie Stage 3 ontology contains 13 terms and has 11 mappings to terms from the HUMAT ontology.

ISSN: 1474-760X