Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools

Table 3 Functional constraints placed on a Myc-E2F pair in promoter sequences

E2F location relative to TSS	[-50, -100]
Myc location relative to TSS	[-100, -150]
Copy number of E2F	1
Copy number of Myc	1
DNA strand of E2F site	+
DNA strand of Myc site	+
Additional space constraint between Myc and E2F sites	[50, 60]

ISSN: 1474-760X