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Figure 2 | Genome Biology

Figure 2

From: Gene expression profiling of Hfe-/-liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

Figure 2

Genes regulated by Hfe deficiency in D2 and B6 liver. A tree view image of k-means clustering for 1,343 genes regulated by Hfe disruption in liver of D2 or B6 mice is shown. Genes were selected by statistical filtering of knockout (KO) versus wild-type (WT) S-scores, as described in Materials and methods. Corresponding values for wild-type D2 versus B6 S-scores are also shown. Red indicates upregulation by Hfe deficiency or more highly expressed in D2 mice; green indicates downregulation by Hfe deficiency or more highly expressed in B6 mice; and black indicates no difference.

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Genome Biology

ISSN: 1474-760X

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