Figure 5

A comparison of Trigger with correlation and model selection for inferring existence causal relationship with CNS1. (a) Significance ranking according to Trigger versus the ranking according to correlation. Although this plot is not calculated conditional on linkage to the CNS1 locus, the plot conditional on linkage yields an equivalent qualitative conclusion. (b) Significance ranking according to Trigger versus the ranking according to model selection. For CNS1 and each gene, AIC was employed to selection among models capturing causality (M1), an inconclusive relationship (M2), linkage only (M3), and independence (M4). The x-axis is broken up into models M1 to M4; within each model type the genes were ranked according to their AIC score. For both correlation and model selection, it can be seen that there is not a strong relationship with Trigger in terms of the ranking, although a ranking in both is clearly necessary for a high Trigger probability. Note that many Trigger probabilities are zero, so the ranking does not extend all of the way to 6,216.