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Table 4 CRP gene haploinsufficiency

From: The ribosomal protein genes and Minute loci of Drosophila melanogaster

CRP genea Genetic analysisb     
Symbol Location CRP gene mutationsc, d Deletions removing a single CRP genec, e Other evidence Is the CRP gene a Minute?f No. of candidate Minute genesg Minute synonymh Referencei
X chromosome         
   RpL36 1B12   M   Yes   M(1)1B [53]
   RpL22 1C4 + +   No    
   sta/RpSA 2B1 + +   No    
   RpL35 5A11    Lies in a gap in deletion coverage. 5A6-13 aneuploids were Minute (Merriam et al. [55]) Likely 33 M(1)5A  
   RpL7A 6B1   M   Likely 2 M(1)5D6A  
   RpL17 6C10    Lies in a gap in deletion coverage Likely 12 New?  
   RpS6 7C2 M M   Yes   M(1)7BC and M(1)7C [2]
   RpS14a 7C6-7    A deletion that removes RpS14a and RpS14b is not Minute [95] No    
   RpS14b 7C8    A deletion that removes RpS14a and RpS14b is not Minute [95] No    
   RpS28b 8E7    Lies in a gap in deletion coverage. A Minute mutation was mapped to 8D8-9A2 [153] Likely 17 M(1)8F  
   RpS15Aa 11E11-12   M   Likely 8 M(1)11F  
   RpL37a 13B1    Lies in a gap in deletion coverage. 12F6-13B6 aneuploids were Minute (Merriam et al. [55]) Likely 2 M(1)13A  
   RpS19a 14F4   M   Likely 14 M(1)14E  
   RpS5a 15E5-7 M   Lies in a gap in deletion coverage Yes   M(1)15D [44]
   RpS10b 18D3 M M   Yes   M(1)18C  
Chromosome arm 2L         
   RpLP1 21C2 M M   Yes   M(2)21C [50]
   oho23B/RpS21 23B6 M M   Yes   M(2)23B [49]
   RpL40 24E1   M   Likely 4 M(2)24D  
   RpL27A 24F3 M M   Yes   M(2)24F  
   RpL37A 25C4   M The interval between flanking non-Minute deletions contains only RpL37A Yes   M(2)25C  
   RpL36A 28D3   M   Likely 5 M(2)28DE*  
   RpS13 29B2 M M   Yes   M(2)29B* [45]
   sop/RpS2 30E1 + +   No    
   RpL13 30F3   M The interval between flanking non-Minute deletions contains only RpL13 Yes   M(2)31A  
   RpL7 31B1   M   Likely 2 M(2)31A  
   RpS27A 31E1   M   Likely 6 M(2)31E*  
   RpL9 32C1 M M   Yes   M(2)32D [46]
   RpL24 34B10   M   Likely 8 M(2)34BC*  
   RpS26 36F4 M M   Yes   M(2)36F  
   RpL30 37B9 + +   No    
   RpL21 40A-B   M   Likely 10 M(2)39F  
   RpL5 40B M M   Yes   M(2)40B* [51]
Chromosome arm 2R         
   RpL38 41C-E M M   Yes   M(2)41A [51]
   RpL31 45F5 M   Lies in a gap in deletion coverage Yes   M(2)45F*  
   RpS15Ab 47C1   +   No    
   RpS11 48E8-9 M   Lies in a gap in deletion coverage Yes   M(2)48E*  
   RpS23 50E4   M   Likely 2 M(2)50E*  
   RpS15 53C8    M(2)531 Minute phenotype rescued by duplication of 51F-54A [154] but not by a RpLP2 transgene [155] Likely 16 M(2)53  
   RpLP2 53C9   M   Likely 5 M(2)53  
   RpL18A 54C3    Lies in a gap in deletion coverage Likely 16 New?  
   RpL11 56D7    Lies in a gap in deletion coverage. 56C-D aneuploids were Minute [55] Likely 3 M(2)56CD  
   RpS18 56F11   M   Likely 2 M(2)56F  
   RpL29 57D8   +   No    
   RpS16 58F1    Deletions that remove both RpS16 and RpS24 are Minute. The Minute mutations M(2)58F1 and RpS24SH2053 complement, suggesting RpS16 is a Minute gene Likely 25 M(2)58F  
   RpS24 58F3 M   Deletions that remove both RpS16 and RpS24 are Minute Yes   M(2)58F  
   RpL23 59B3   +   No    
   RpL37b 59C4   +   No    
   RpL12 60B7    RpL12 and RpL39 lie in the same gap in deletion coverage. 60B3-10 aneuploids were Minute [156] Likely 9 M(2)60B  
   RpL39 60B7    RpL12 and RpL39 lie in the same gap in deletion coverage. 60B3-10 aneuploids were Minute [156] Likely 9 M(2)60B  
   RpL41 60E5 + +   No    
   RpL19 60E11 M   A deletion that removes RpL19 and RpL41 is Minute Yes   M(2)60E [42]
Chromosome arm 3L         
   RpL23A 62A10   M   Likely 8 M(3)62A  
   RpL8 62E7    Lies in a gap in deletion coverage containing only RpL8. 62E-63A aneuploids were Minute [54] Yes   M(3)62F  
   RpL28 63B14   M   Likely 10 M(3)63B  
   RpL18 65E9   M   Likely 8 M(3)65F  
   RpL14 66D8 M   Lies in a gap in deletion coverage Yes   M(3)66D [47]
   RpS17 67B5    A deletion removing both RpS17 and RpS9 is Minute. The unsequenced Minute mutations RpS174 and RpS176 complement the Minute mutation RpS9EP3299, suggesting RpS17 is a Minute gene Likely 13 M(3)67C  
   RpS9 67B11 M   A deletion removing both RpS17 and RpS9 is Minute Yes   M(3)67C  
   RpL10Ab 68E1   +   No    
   RpS12 69F5   + A deletion that removes RpS12 and RpS4 is Minute No    
   RpS4 69F6    A deletion that removes RpS12 and RpS4 is Minute Likely 2 M(3)69E  
   RpL26 75E4   +   No    
   RpLP0 79B2 + +   No    
   Qm/RpL10 80A   M   Likely 23 M(3)80  
   RpL15 80F   M   Likely = 11 M(3)80F*  
Chromosome arm 3R         
   RpL35A 83A4    Lies in a gap in deletion coverage Likely 3 New?  
   RpL13A 83B6-7 M   Lies in a gap in deletion coverage Yes   M(3)83B* [52]
   RpL34b 85D15    Lies in a gap in deletion coverage Likely 3 New?  
   RpS29 85E8 M M   Yes   M(3)85E  
   RpS25 86D8    A deletion that removes RpS25 and RpL3 is Minute Likely 14 M(3)86D  
   RpL3 86D8 +    No    
   RpS5b 88D6 + +   No    
   RpL10Aa 88D10   +   No    
   RpS20 93A1    A deletion that removes RpS20 and RpS30 is Minute Likely 21 M(3)93A*  
   RpS30 93A2    A deletion that removes RpS20 and RpS30 is Minute Likely 21 M(3)93A*  
   RpS3 94E13 M M   Yes   M(3)95A [43]
   RpS19b 95C13   +   No    
   RpS27 96C8   M   Likely 5 M(3)96C  
   RpL27 96E9-10   M   Likely 6 M(3)96CF  
   RpL34a 96F10   +   No    
   RpS10a 98A14   +   No    
   RpL4 98B6   M   Likely 6 M(3)98B*  
   RpS8 99C4    Lies in a gap in deletion coverage. 99B aneuploids were Minute [157] Likely 11 M(3)99B  
   RpS28a 99D2    The Minute phenotype of a deletion removing RpS28a and RpL32 is rescued by a RpL32 transgene [41] No    
   RpL32 99D3    The Minute phenotype of a deletion removing RpS28a and RpL32 is rescued by a RpL32 transgene [41] Yes   M(3)99D [41]
   RpS7 99E2    Lies in a gap in deletion coverage. 99E-F aneuploids were Minute [157] Likely 11 M(3)99E  
   RpL6 100C7    Lies in a gap in deletion coverage. 100C-F aneuploids were Minute [157] Likely 16 M(3)100CF  
Chromosome 4         
   RpS3A 101F1 M M   Yes   M(4)101 [48]
  1. aBold font indicates the member of a duplicate gene pair that is expressed in a small number of tissues and/or at relatively low levels. bComplete details are given in Additional data file 4. c'M' indicates that mutation or deletion heterozygotes display a Minute bristle phenotype; '+' indicates they are wild type; a blank indicates the absence of appropriate mutations or deletions. dMutations mapped molecularly to a single CRP gene. eDeletions removing several genes, but only a single CRP gene. fJudged according to evidence summarized in previous three columns and presented in detail in Additional data file 4. gThe maximum number of genes that could correspond to the Minute; defined as the number of genes between the relevant deletion breakpoints minus the number of genes with non-Minute mutations. hMinute synonyms from literature sources (see Additional data files 3 and 4). Asterisks indicate new synonyms assigned in this study. iReference demonstrating definite correspondence between a Minute locus and CRP gene. Where no reference is given, the correspondence is shown for the first time in this study.