Perturbation of gene expression of the chromatin remodeling pathway in premature newborns at risk for bronchopulmonary dysplasia

Table 5 Differentially expressed pathways in infants with BPD versus infants without BPD

Gene set/pathway	NT_k q value	NE_k q value
Regulation of cell growth (GO:0001558)	0.0	0.0
Nuclear pore complex (GO:0046930)	0.0	0.03
Negative regulation of cellular metabolism (GO:0031324)	0.0	0.04
Chromatin remodeling (GO:0016568)	0.0	0.055
PI3K-AKT signaling pathway (humanpaths)	0.0	0.1
Histone acetyltransferase binding (GO:0035035)	0.0	0.2
cAMP/Ca²⁺ signaling (humanpaths)	0.0	0.3
Spliceosome complex (GO:0005681)	0.0	0.9

Shown here are the pathways (with redundant pathways removed as well as those that overlapped with Table 4) that were ranked at the top of the list of those differentially expressed by two measures of false discovery: the NT_k q value and the NE_k q value. The NT_k q value corresponds to the degree to which genes within a set/pathway are more predictive of the phenotype than the genes outside that set, and the NE_k q value corresponds to the degree to which genes within that set are predictive of the phenotype. Only those pathways with an NT_k q value below 10^-4 and a NE_k q value below 1 are shown above. Each pathway is annotated by ontology source (Gene Ontology [GO] or humanpaths). BPD, bronchopulmonary dysplasia; PI3K, phosphoinositide-3 kinase.

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