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Table 6 High quality candidates for the defective thymic deletion allele linked to D1mit181

From: Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Gene Probeset Group Distance (cM) Fold change Function
Dnajb10 1448657_a_at 3 0.5 1.7 Homology to heat shock protein DnaJ (Hsp40)
Dnpep 1437437_x_at 1 0.5 1.6 Putative aspartyl aminopeptidase function
Farslb 1423708_a_at 3 2.5 2.0 Phenylalanine-tRNA synthetase-like, beta subunit
Acadl 1448987_at 3 4.8 1.9 Involved in the initial step of mitochondrial beta-oxidation of straight-chain fatty acids
Pdcd1 1449835_at 1 11.8 1.9 Negative regulator of T cell function [77], reduces positive selection [78], blockade induces diabetes in NOD mice [81], KO has autoimmune symptoms [79,80]
Rps24 1453362_x_at 3 12.0 3.5 Ribosome constituent
Hspa8 1420622_a_at 1 17.6 2.0 Aid in the targeting of the MHC class II complex to endocytic compartments [98], regulates cell cycle [99]
Prim2 1418035_a_at 3 25.7 3.7 DNA primase [100] involved in primer initiation, elongation, and counting [101]
  1. KO, knockout.