Table 6 High quality candidates for the defective thymic deletion allele linked to D1mit181
Gene | Probeset | Group | Distance (cM) | Fold change | Function |
|---|---|---|---|---|---|
Dnajb10 | 1448657_a_at | 3 | 0.5 | 1.7 | Homology to heat shock protein DnaJ (Hsp40) |
Dnpep | 1437437_x_at | 1 | 0.5 | 1.6 | Putative aspartyl aminopeptidase function |
Farslb | 1423708_a_at | 3 | 2.5 | 2.0 | Phenylalanine-tRNA synthetase-like, beta subunit |
Acadl | 1448987_at | 3 | 4.8 | 1.9 | Involved in the initial step of mitochondrial beta-oxidation of straight-chain fatty acids |
Pdcd1 | 1449835_at | 1 | 11.8 | 1.9 | Negative regulator of T cell function [77], reduces positive selection [78], blockade induces diabetes in NOD mice [81], KO has autoimmune symptoms [79,80] |
Rps24 | 1453362_x_at | 3 | 12.0 | 3.5 | Ribosome constituent |
Hspa8 | 1420622_a_at | 1 | 17.6 | 2.0 | Aid in the targeting of the MHC class II complex to endocytic compartments [98], regulates cell cycle [99] |
Prim2 | 1418035_a_at | 3 | 25.7 | 3.7 | DNA primase [100] involved in primer initiation, elongation, and counting [101] |