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Table 4 High quality candidates for D15mit229-linked defective thymic deletion

From: Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Gene

Probeset

Group

Distance (cM)

Fold change

Function

Oxr1

1418502_a_at

1

0.1

2.7

Protection against oxidative damage [91]

6030458C11Rik

1433860_at

6

18.1

1.5

Unknown

Ly6c

1421571_a_at

3

21.1

2.3

Inhibits signal for secretion of IL2 and proliferation [65], cross-linking causes clustering of LFA-1 [66]

Fbxl6

1449849_a_at

3

22.0

3.1

Unknown

Rpl8

1417762_a_at

3

22.3

1.9

Structural constituent of ribosomes

Phf5a

1424170_at

3

25.4

2.1

Nuclear protein, possibly chromatin binding [92]

  1. LFA, Leukocyte function associated molecule.