Figure 4

Graphical representation of expression changes between the B10^k and NOD^k strains. Probesets falling in specific B10^k clusters were assessed for the ratio of expression during negative selection in NOD^k:B10^k mice. A value of 1 represents equal expression during negative selection, <1 represents lower expression in NOD^k thymocytes than B10^k thymocytes during negative selection, and >1 represents higher expression in NOD^k thymocytes than B10^k thymocytes during negative selection. (a) Probeset patterns from the B10^k analysis increased (D, E, L) or decreased (J, K, F) specifically during negative selection trended towards showing that the same probeset in NOD^k thymocytes had a lower/higher expression, respectively. (b) The probeset pattern from the B10^k analysis increased during maturation (A) showed roughly the same level of expression during negative selection in NOD^k thymocytes (divided into random groups for clarity).