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Table 5 Accuracy of human gene prediction using similar mouse proteins

From: Automatic annotation of eukaryotic genes, pseudogenes and promoters

  Sn ex Sno ex Sp ex Sn nuc Sp nuc CC %CG
Similarity of mouse protein >90% in 921 sequences
   Fgenesh 86.2 91.7 88.6 93.9 93.4 0.9334 34
   Genwise 93.9 97.6 95.9 99.0 99.6 0.9926 66
   Fgenesh+ 97.3 98.9 98.0 99.1 99.6 0.9936 81
   Prot_map 95.9 98.3 96.9 99.1 99.5 0.9924 73
80% < similarity of mouse protein <90% in 1,441 sequences
   Fgenesh 85.8 92.1 87.7 94.0 93.4 0.9334 30
   Genewise 92.6 98.0 94.1 98.9 99.5 0.9912 58
   Fgenesh+ 96.8 99.0 97.2 99.1 99.5 0.9929 77
   Prot_map 93.9 98.5 94.1 98.9 99.3 0.9898 60
  1. Sn_ex, sensitivity on the exon level (exact exon predictions); Sno_ex, sensitivity with exon overlap; Sp_ex, specificity on the exon level; Sn_nuc, sensitivity, nucleotides; Sp_nuc, specificity, nucleotides; CC, correlation coefficient; %CG, percent of genes predicted completely correctly (no missing and no extra exons, and all exon boundaries are predicted exactly correctly).