Comparative sequence analysis reveals an intricate network among REST, CREBand miRNA in mediating neuronal gene expression

Table 2 Enriched motifs in the regulatory regions of brain-related miRNAs

Motif	Conserved Num	Total number	Conservation rate	Neutral conservation rate	Z-score	Factor*	Factor consensus^†	Similarity score^‡
GACGTCA	20	33	0.61	0.069	11.7	CREB	TGACGTCA	0.95
CCATCTG	31	127	0.24	0.058	8.7	E47	AMCATCTGTT	0.93
ATAACCG	8	11	0.73	0.069	8.3
AGACGCG	8	12	0.67	0.069	7.9
TGAGTCA	20	83	0.24	0.058	6.9	Bach2	SRTGAGTCANC	0.97
AACAAAG	22	107	0.21	0.058	6.3	LEF-1	SWWCAAAGGG	0.81
AGATAAC	14	54	0.26	0.058	6.1	GATA-1	CWGATAACA	0.89
GCAGCTG	29	183	0.16	0.058	5.6	LBP-1	SCAGCTG	0.94
ATGCGCA	8	20	0.40	0.069	5.6
CCTTTGT	17	82	0.21	0.058	5.6	LEF-1	CCCTTTGWWS	0.86
ACAGCAA	18	90	0.20	0.058	5.6
ATGGCTT	17	84	0.20	0.058	5.5
CTGCCAG	28	181	0.16	0.058	5.4
GCGCCAT	7	17	0.41	0.069	5.4
CGCACGC	7	17	0.41	0.069	5.4	AhR	CACGCNA	0.86
GGTGCTA	11	44	0.25	0.058	5.3
CAATAAA	19	107	0.18	0.058	5.1
GCGCGTC	8	23	0.35	0.069	5.1
GTCTGTC	13	61	0.21	0.058	5.0	SMAD3	TGTCTGTCT	0.89
ATTAAGG	13	61	0.21	0.058	5.0	Nkx2-5	CAATTAWG	0.82
TGACAAG	13	63	0.21	0.058	4.9
ATTAACT	12	56	0.21	0.058	4.9
GGGATTA	10	42	0.24	0.058	4.8	PITX2	YTGGGATTANW	0.93
ATGCTAA	11	49	0.22	0.058	4.8	POU3F2	TTATGYTAAT	0.82
GCACAAA	13	64	0.20	0.058	4.8
CCACCTG	22	144	0.15	0.058	4.7	MyoD	TNCNNCACCTG	0.88
AATTAAA	21	135	0.16	0.058	4.7	NKX6-1	AACCAATTAAAW	0.93
TGCAAAT	17	99	0.17	0.058	4.7	Oct1	TATGCAAAT	0.93
CTAATTG	8	31	0.26	0.058	4.6	S8	GNTAATTRR	0.86
CGCTGAC	7	21	0.33	0.069	4.6
CACCAGG	18	110	0.16	0.058	4.6
TCAATAA	13	68	0.19	0.058	4.6	HNF-6	HWAAATCAATAW	0.8
TTTGCAT	17	102	0.17	0.058	4.6	Oct1	ATTTGCATA	0.96

*Transcription factors from Transfac database. ^†Known consensus in Transfac database that is similar to the 7-mer. ^‡Measure the similarity between the 7-mer and the Transfac factor consensus. The score ranges from 0 to 1, with 1 for two identical consensus sequences.

ISSN: 1474-760X