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Table 2 Enriched motifs in the regulatory regions of brain-related miRNAs

From: Comparative sequence analysis reveals an intricate network among REST, CREBand miRNA in mediating neuronal gene expression

Motif Conserved Num Total number Conservation rate Neutral conservation rate Z-score Factor* Factor consensus Similarity score
GACGTCA 20 33 0.61 0.069 11.7 CREB TGACGTCA 0.95
CCATCTG 31 127 0.24 0.058 8.7 E47 AMCATCTGTT 0.93
ATAACCG 8 11 0.73 0.069 8.3    
AGACGCG 8 12 0.67 0.069 7.9    
TGAGTCA 20 83 0.24 0.058 6.9 Bach2 SRTGAGTCANC 0.97
AACAAAG 22 107 0.21 0.058 6.3 LEF-1 SWWCAAAGGG 0.81
AGATAAC 14 54 0.26 0.058 6.1 GATA-1 CWGATAACA 0.89
GCAGCTG 29 183 0.16 0.058 5.6 LBP-1 SCAGCTG 0.94
ATGCGCA 8 20 0.40 0.069 5.6    
CCTTTGT 17 82 0.21 0.058 5.6 LEF-1 CCCTTTGWWS 0.86
ACAGCAA 18 90 0.20 0.058 5.6    
ATGGCTT 17 84 0.20 0.058 5.5    
CTGCCAG 28 181 0.16 0.058 5.4    
GCGCCAT 7 17 0.41 0.069 5.4    
CGCACGC 7 17 0.41 0.069 5.4 AhR CACGCNA 0.86
GGTGCTA 11 44 0.25 0.058 5.3    
CAATAAA 19 107 0.18 0.058 5.1    
GCGCGTC 8 23 0.35 0.069 5.1    
GTCTGTC 13 61 0.21 0.058 5.0 SMAD3 TGTCTGTCT 0.89
ATTAAGG 13 61 0.21 0.058 5.0 Nkx2-5 CAATTAWG 0.82
TGACAAG 13 63 0.21 0.058 4.9    
ATTAACT 12 56 0.21 0.058 4.9    
GGGATTA 10 42 0.24 0.058 4.8 PITX2 YTGGGATTANW 0.93
ATGCTAA 11 49 0.22 0.058 4.8 POU3F2 TTATGYTAAT 0.82
GCACAAA 13 64 0.20 0.058 4.8    
CCACCTG 22 144 0.15 0.058 4.7 MyoD TNCNNCACCTG 0.88
AATTAAA 21 135 0.16 0.058 4.7 NKX6-1 AACCAATTAAAW 0.93
TGCAAAT 17 99 0.17 0.058 4.7 Oct1 TATGCAAAT 0.93
CTAATTG 8 31 0.26 0.058 4.6 S8 GNTAATTRR 0.86
CGCTGAC 7 21 0.33 0.069 4.6    
CACCAGG 18 110 0.16 0.058 4.6    
TCAATAA 13 68 0.19 0.058 4.6 HNF-6 HWAAATCAATAW 0.8
TTTGCAT 17 102 0.17 0.058 4.6 Oct1 ATTTGCATA 0.96
  1. *Transcription factors from Transfac database. Known consensus in Transfac database that is similar to the 7-mer. Measure the similarity between the 7-mer and the Transfac factor consensus. The score ranges from 0 to 1, with 1 for two identical consensus sequences.