Figure 1From: Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolutionCombinatorial RNA interference (RNAi) can target two genes in the same animal. Exposing worms to a mixture of two double-stranded (ds)RNA-expressing bacterial clones, one targeting lin-31 and the other one targeting sma-4, resulted in small worms with multiple vulvae along their ventral side. Shown are RNAi-hypersensitive rrf-3 animals [19] fed on bacteria expressing (a) a nontargeting dsRNA (control) and (b) combined bacterial clones expressing dsRNA against lin-31 and sma-4 (magnified in (c)). Pseudovulvae are indicated by white arrowheads.Back to article page