Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineage

Table 1 Transcription potential, localization, and number of mammalian rCNEs

rCNE type^a	Total^b	Coding^c	Noncoding^d
Total^e	364,358	82,714	281,644
Pre-gene^f	120,001	23,832	96,169
Intronic^g	158,722	29,002	129,720
Post-gene^h	85,521	29,766	55,755

^aType of conserved non-coding sequence (rCNE). ^bTotal number of rCNEs, including genic and nongenic. ^cNumber of genic rCNEs: overlapping EMBL proteins, ESTs, GenScan predictions, and Ensembl genes. ^dNumber of nongenic rCNEs: not overlapping EMBL proteins, ESTs, GenScan, and Ensembl genes. ^eTotal number of rCNEs, including pre-gene, intronic and post-gene. ^fNumber of pre-gene rCNEs: rCNEs localized before the translation start of the reference gene. ^gNumber of intronic rCNEs: rCNEs localized within the introns of the reference gene. ^hNumber of post-gene rCNEs: rCNEs localized after the translation end of the reference gene. EST, expressed sequence tag; rCNE, regionally conserved non-coding element.

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