Figure 2From: Design principles of molecular networks revealed by global comparisons and composite motifsAnalysis of the essentiality of hubs and composite hubs. (a) Comparison of the percentages of essential genes in hubs and non-hubs in different networks. P values measure the significance of differences between the percentages for hubs and non-hubs. (b) Comparison of the percentages of essential genes in non-hubs, hubs and composite hubs. In this figure, we excluded all composite hubs when calculating the percentage for hubs. Due to the limited number of tri-hubs, we combined them with bi-hubs. P values measure the significance of the differences between neighboring bars. Met, the metabolic network; Int, the interaction network; Exp, the co-expression network; and Reg, the regulatory network (in Figures 2 and 3, we only consider the regulator population in the regulatory network).Back to article page