From: Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling
Gene group | Attribute class | Attribute | p ENRICH | p ENRICH (FDR) | No. of genes | GFRAC | AFRAC | ENRICH | p M (LOCAL) | p M (GLOBAL) |
---|---|---|---|---|---|---|---|---|---|---|
Any EGF effect | GO | Cell differentiation | 3.E-03 | 0.08 | 7 | 0.1 | 0.3 | 3.4 | 0.02 | 0.06 |
 |  | Protein kinase activity | 0.01 | 0.10 | 10 | 0.2 | 0.2 | 2.4 | 0.03 | 0.08 |
 |  | Protein serine/threonine kinase activity | 2.E-03 | 0.08 | 10 | 0.2 | 0.2 | 2.8 | 0.01 | 0.06 |
 | PAINT | ATF3 | 0.02 | 0.16 | 5 | 0.1 | 0.3 | 2.9 | 0.02 | 0.52 |
 |  | CREB | 4.E-03 | 0.06 | 9 | 0.1 | 0.3 | 2.7 | 4.E-03 | 0.10 |
 |  | CREBATF | 3.E-03 | 0.06 | 5 | 0.1 | 0.5 | 4.3 | 0.04 | 0.59 |
 |  | CRE-BP1:c-Jun | 0.01 | 0.14 | 7 | 0.1 | 0.3 | 2.6 | 0.02 | 0.31 |
 | CONS | V$AP1_2 | 0.02 | 0.90 | 71 | 0.8 | 0.1 | 1.1 | 0.03 | 0.11 |
 |  | V$AP1_C | 1.E-03 | 0.16 | 53 | 0.6 | 0.2 | 1.4 | 2.E-03 | 0.06 |
 |  | V$CEBP_Q2 | 0.01 | 0.54 | 32 | 0.4 | 0.2 | 1.4 | 0.01 | 0.03 |
 |  | V$CEBP_Q2_01 | 0.03 | 0.90 | 61 | 0.7 | 0.1 | 1.2 | 0.05 | 0.06 |
 |  | V$CEBP_Q3 | 2.E-03 | 0.19 | 69 | 0.8 | 0.1 | 1.2 | 2.E-03 | 0.02 |
 |  | V$CEBPGAMMA_Q6 | 0.03 | 0.90 | 26 | 0.3 | 0.2 | 1.4 | 0.05 | 0.07 |
 |  | V$OCT1_07 | 0.02 | 0.90 | 10 | 0.1 | 0.2 | 2.0 | 0.05 | 0.23 |
 |  | V$RORA1_01 | 7.E-05 | 0.02 | 21 | 0.2 | 0.3 | 2.3 | 3.E-04 | 2.E-03 |
 |  | V$RORA2_01 | 0.01 | 0.54 | 6 | 0.1 | 0.4 | 3.1 | 0.06 | 0.19 |
 | Circ. | SCN circadian genes [17] | 0.04 | - | 16 | 0.1 | 0.4 | 1.5 | 0.02 | - |
EGF:CT | GO | Cell differentiation | 1.E-03 | 0.06 | 6 | 0.1 | 0.2 | 4.5 | 0.01 | 0.05 |
interaction | PAINT | c-Ets-1/68 | 0.07 | 0.36 | 8 | 0.1 | 0.2 | 1.8 | 0.06 | 0.13 |
 |  | CREB | 0.01 | 0.10 | 7 | 0.1 | 0.2 | 2.7 | 0.01 | 0.11 |
 |  | CREBATF | 8.E-04 | 0.02 | 5 | 0.1 | 0.5 | 5.7 | 0.02 | 0.60 |
 |  | CRE-BP1:c-Jun | 0.01 | 0.10 | 6 | 0.1 | 0.3 | 3.0 | 0.01 | 0.23 |
 |  | E2F | 0.03 | 0.20 | 5 | 0.1 | 0.2 | 2.7 | 0.02 | 0.28 |
 | CONS | V$AP1_C | 2.E-04 | 0.03 | 41 | 0.7 | 0.1 | 1.5 | 2.E-03 | 0.05 |
 |  | V$CEBP_Q2 | 2.E-03 | 0.11 | 26 | 0.4 | 0.1 | 1.7 | 0.01 | 0.07 |
 |  | V$CEBP_Q3 | 5.E-03 | 0.26 | 49 | 0.8 | 0.1 | 1.2 | 0.01 | 0.09 |
 |  | V$CETS1P54_01 | 0.03 | 0.71 | 46 | 0.7 | 0.1 | 1.2 | 0.05 | 0.13 |
 |  | V$CREBP1_Q2 | 0.03 | 0.71 | 8 | 0.1 | 0.2 | 2.1 | 0.04 | 0.36 |
 |  | V$ER_Q6_02 | 0.02 | 0.69 | 30 | 0.5 | 0.1 | 1.4 | 0.01 | 0.10 |
 |  | V$HFH4_01 | 0.01 | 0.31 | 8 | 0.1 | 0.2 | 2.7 | 0.01 | 0.08 |
 |  | V$RORA1_01 | 2.E-04 | 0.03 | 16 | 0.3 | 0.2 | 2.5 | 1.E-03 | 4.E-03 |
 |  | V$RORA2_01 | 1.E-03 | 0.11 | 6 | 0.1 | 0.4 | 4.4 | 0.03 | 0.14 |
 | ChIP | HNF1-alpha | 0.04 | 0.11 | 6 | 0.1 | 0.2 | 2.3 | 0.15 | 0.25 |
 | Circ. | SCN circadian genes [17] | 0.05 | - | 13 | 0.1 | 0.3 | 1.6 | 0.07 | - |
EGF without interaction | GO | Protein binding | 0.02 | 0.06 | 7 | 0.3 | 0.1 | 2.5 | 0.01 | 0.06 |
 |  | Protein kinase activity | 2.E-03 | 0.02 | 6 | 0.3 | 0.1 | 4.2 | 0.03 | 0.37 |
 |  | Protein serine/threonine kinase activity | 1.E-03 | 0.02 | 6 | 0.3 | 0.1 | 4.8 | 0.02 | 0.32 |
 |  | Transferase activity | 2.E-03 | 0.02 | 9 | 0.4 | 0.1 | 2.8 | 0.04 | 0.22 |
 | CONS | V$CEBPGAMMA_Q6 | 0.02 | 1 | 11 | 0.4 | 0.1 | 1.9 | 0.01 | 0.08 |
 |  | V$TFIIA_Q6 | 0.02 | 1 | 12 | 0.4 | 0.1 | 1.8 | 0.03 | 0.04 |
EGF: day+night | CONS | V$CREB_Q2 | 2.E-03 | 0.15 | 5 | 0.4 | 0.1 | 4.8 | 0.01 | 0.65 |
 |  | V$CREB_Q4 | 9.E-04 | 0.12 | 6 | 0.5 | 0.1 | 4.5 | 4.E-03 | 0.55 |
 |  | V$CREB_Q4_01 | 4.E-03 | 0.19 | 7 | 0.5 | 0.05 | 2.9 | 0.01 | 0.50 |
 | ChIP | CREB (relaxed) | 0.11 | 0.11 | 6 | 0.5 | 0.03 | 1.7 | 0.24 | 0.35 |
EGF: night only | CONS | V$AP1_C | 3.E-03 | 0.14 | 27 | 0.7 | 0.1 | 1.5 | 0.03 | 0.17 |
 |  | V$CEBP_Q2 | 6.E-04 | 0.13 | 20 | 0.5 | 0.1 | 2.0 | 0.01 | 0.08 |
 |  | V$CEBP_Q2_01 | 0.02 | 0.40 | 31 | 0.8 | 0.1 | 1.3 | 0.04 | 0.16 |
 |  | V$CEBP_Q3 | 5.E-03 | 0.16 | 34 | 0.8 | 0.1 | 1.3 | 0.01 | 0.09 |
 |  | V$CREBP1_01 | 0.01 | 0.31 | 8 | 0.2 | 0.1 | 2.5 | 0.03 | 0.04 |
 |  | V$ER_Q6_02 | 4.E-03 | 0.16 | 23 | 0.6 | 0.1 | 1.6 | 0.02 | 0.15 |
 |  | V$HFH4_01 | 2.E-03 | 0.13 | 7 | 0.2 | 0.2 | 3.6 | 4.E-03 | 0.20 |
 |  | V$LMO2COM_02 | 0.02 | 0.43 | 29 | 0.7 | 0.1 | 1.3 | 0.06 | 0.13 |
 |  | V$RORA1_01 | 2.E-03 | 0.13 | 11 | 0.3 | 0.1 | 2.6 | 0.01 | 0.01 |
 |  | V$RORA2_01 | 1.E-03 | 0.13 | 5 | 0.1 | 0.3 | 5.5 | 0.02 | 0.08 |