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Table 1 DDI-PPI mapping: all protein interactions

From: Evolutionary conservation of domain-domain interactions

Organisma E. coli yeast worm fly human
Number of PPIsb 6,934 24,699 5,315 24,703 28,800
Number of PPIs with known domainsc (N) 6,038 18,202 3,351 14,939 25,004
Number of PPIs to which DDIs could be mappedd (n) (%; n/N*100)
Median value of random networks (P value)
806 (13%)
295 (<0.001)
1,660 (9%)
363 (<0.001)
375 (11%)
142 (<0.001)
891 (6%)
276 (<0.001)
4,924 (20%)
911 (<0.001)
No. of PPIs to which DDIs could be mapped, disregarding PPI-DDI mappings due to overlap between the structural database and the PPI data (n)(%; n/N*100)
Median value of random networks (P value)
755 (13%) 288 (<0.001) 1608 (9%)
353 (<0.001)
375 (11%)
142 (<0.001)
889 (6%)
276 (<0.001)
3,989 (16%)
856 (<0.001)
  1. aOrganism labeling: yeast, S. cerevisiae; worm, C. elegans; fly, D. melanogaster. bSee Figure 1a. cSee Figure 1c. dSee Figure 1e. DDI, domain-domain interaction; PPI, protein-protein interaction.