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Table 1 The chemokine superfamily

From: The chemokine and chemokine receptor superfamilies and their molecular evolution

CXC family

Human

Other names

Chromosome

Function

Cluster

Mouse

Other names

Chromosome

Function

Cluster

Receptor

CXCL1

Groα

4q13.3

I

GRO

Cxcl1*

Gro/KC

5qE2

I

GRO

CXCR2, CXCR1

CXCL2

Groβ

4q13.3

I

GRO

Cxcl2*

MIP-2

5qE2

I

GRO

CXCR2

CXCL3

Groγ

4q13.3

I

GRO

Gm1960*

Dcip1

5qE2

I

GRO

CXCR2

CXCL4

PF4

4q13.3

U

GRO

Cxcl4*

PF4

5qE2

U

GRO

CXCR3B†

CXCL4V1

 

4q13.3

U

GRO

      

CXCL5

ENA-78

4q13.3

I

GRO

Cxcl5*

LIX

5qE2

I

GRO

CXCR2

CXCL6

GCP-2

4q13.3

I

GRO

     

CXCR1, CXCR2

CXCL7

NAP-2

4q13.3

I

GRO

Cxcl7

Ppbp

5qE2

I

GRO

Unknown

CXCL8

IL-8

4q13.3

I

GRO

Unknown

    

CXCR1, CXCR2

CXCL9

MIG

4q21.1

I

IP10

Cxcl9

MIG

5qE3

I

IP10

CXCR3, CXCR3B

CXCL10

IP-10

4q21.1

I

IP10

Cxcl10

IP-10

5qE3

I

IP10

CXCR3, CXCR3B

CXCL11

I-TAC

4q21.1

I

IP10

Cxcl11

I-TAC

5qE3

I

IP10

CXCR3, CXCR3B, CXCR7‡

CXCL12

SDF-1α/β

10q11.21

H

 

Cxcl12

SDF-1α/β

6qF1

H

 

CXCR4, CXCR7‡

CXCL13

BLC, BCA-1

4q21.1

H

IP10

Cxcl13

BLC, BCA-1

5qE3

H

IP10

CXCR5

CXCL14

BRAK, Bolekine

5q31.1

I

 

Cxcl14

BRAK

13qB2

I

 

Unknown

Unknown

    

Cxcl15

Lungkine, Weche

5qE2

U

 

Unknown

CXCL16

 

17p13.2

I

 

Cxcl16

Cxcl16

11qB4

I

 

CXCR6

CXCL17

DMC

19q13.2

U

 

Cxcl17

DMC

7qA3

U

 

Unknown

CC family

CCL1

I-309

17q11.2

I

MCP

Ccl1

TCA-3

11qB5

I

MCP

CCR8

CCL2

MCP-1

17q11.2

I

MCP

Ccl2

JE

11qB5

I

MCP

CCR2

CCL3

MIP-1α, LD78α

17q11.2

I

MIP

Ccl3*

MIP-1α

11qB5

I

MIP

CCR1, CCR5

CCL3L1

LD78β

17q12

I

MIP

      

CCL3L3

LD78β

17q12

I

MIP

      

CCL4

MIP-1β

17q12

I

MIP

Ccl4*

MIP-1β

11qB5

I

MIP

CCR5

CCL4L1

AT744.2

17q12

I

MIP

      

CCL4L2

 

17q12

I

MIP

      

CCL5

RANTES

17q12

I

 

Ccl5

RANTES

11qB5

I

 

CCR1, CCR3, CCR5

CCL7

MCP-3

17q11.2

I

MCP

Ccl7

MARC

11qB5

 

MCP

CCR1, CCR2, CCR3

CCL8

MCP-2

17q11.2

I

MCP

Ccl8*, Ccl12*

MCP-2, MCP-5

11qB5

I

MCP

CCR1, CCR2, CCR3, CCR5

CCL11

Eotaxin

17q11.2

I

MCP

Ccl11

Eotaxin

11qB5

I

MCP

CCR3

CCL13

MCP-4

17q11.2

I

MCP

Unknown

   

MCP

CCR1, CCR2, CCR3

CCL14

HCC-1

17q12

H

MIP

Unknown

    

CCR1

CCL15

HCC-2

17q12

H

MIP

Ccl9

MMRP2, CCF18, MIP-1γ

11qB5

H

MIP

CCR1, CCR3

CCL16

HCC-4 LEC

17q12

H

MIP

Pseudogene

 

11qB5

 

MIP

CCR1, CCR2, CCR5, HRH4§

CCL17

TARC

16q13

D

MIP

Ccl17

TARC

8qC5

D

 

CCR4

CCL18

PARC

17q12

H

 

Pseudogene

    

Unknown

CCL19

MIP3β, ELC

9p13.3

H

 

Ccl19

MIP3β

4qB1

H

 

CCR7

CCL20

MIP3α, LARC

2q36.3

D

 

Ccl20

MIP3α, LARC

1qC5

D

 

CCR6

CCL21

SLC

9p13.3

D

 

Ccl21a, Ccl21b, Ccl21c*

SLC

4qB1

D

 

CCR7

CCL22

MDC

16q13

D

 

Ccl22

ABCD-1

8qC5

D

 

CCR4

CCL23

MPIF-1

17q12

I

MIP

Ccl6

C10

11qB5

I

MIP

CCR1, FPRL-1¶

CCL24

Eotaxin 2

7q11.23

I

 

Ccl24

Eotaxin 2

5qG1

I

 

CCR3

CCL25

TECK

19p13.2

H

 

Ccl25

TECK

8qA1.2

H

 

CCR9

CCL26

Eotaxin 3

7q11.23

I

 

Ccl26l

Eotaxin 3-like

5qG1

I

 

CCR3

CCL27

CTACK, ILC

9p13.3

H

 

Ccl27a,b*

CTACK, ILC

4qB1

H

 

CCR10

CCL28

MEC

5p12

U

 

Ccl28

MEC

13

U

 

CCR10, CCR3

Other classes

XCL1

Lymphotactin, SCM-1α

1q24.2

D

 

Xcl1*

Lymphotactin

1qH2

D

 

XCR1

XCL2

SCM-1β

1q24.2

D

       

CX3CL1

Fractalkine

16q13

I

 

Cx3cl1

Fractalkine

8qC5

I

 

CX3CR1

  1. Functions are as follows: I, inflammatory; H, homeostatic; D, dual (homeostatic and inflammatory); U, unknown. The lists of alternative names are not comprehensive. Chromosomal location data are derived from the Ensembl [39] or Mouse Genome Informatics [40] databases. GRO, GRO region of the CXC major gene cluster; IP10, IP10 region of the CXC major gene cluster; MCP, MCP region of the CC major gene cluster; MIP, MIP region of the CC major gene cluster. *See also Figure 2. †An alternatively spliced variant of CXCR3 that has been reported to mediate the ability of CXCL4, CXCL9, CXCL10 and CXCL11 to control angiogenesis. ‡Binding has been reported, but signaling is still controversial. §CCL16 has been reported to bind and signal through histamine receptor type 4. ¶A splice variant of CCL23 has been reported to bind to and signal through formyl peptide receptor like-1 (FPRL-1).
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Genome Biology

ISSN: 1474-760X

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