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Table 1 The chemokine superfamily

From: The chemokine and chemokine receptor superfamilies and their molecular evolution

CXC family
Human Other names Chromosome Function Cluster Mouse Other names Chromosome Function Cluster Receptor
CXCL1 Groα 4q13.3 I GRO Cxcl1* Gro/KC 5qE2 I GRO CXCR2, CXCR1
CXCL2 Groβ 4q13.3 I GRO Cxcl2* MIP-2 5qE2 I GRO CXCR2
CXCL3 Groγ 4q13.3 I GRO Gm1960* Dcip1 5qE2 I GRO CXCR2
CXCL4 PF4 4q13.3 U GRO Cxcl4* PF4 5qE2 U GRO CXCR3B†
CXCL4V1   4q13.3 U GRO       
CXCL5 ENA-78 4q13.3 I GRO Cxcl5* LIX 5qE2 I GRO CXCR2
CXCL6 GCP-2 4q13.3 I GRO       CXCR1, CXCR2
CXCL7 NAP-2 4q13.3 I GRO Cxcl7 Ppbp 5qE2 I GRO Unknown
CXCL8 IL-8 4q13.3 I GRO Unknown      CXCR1, CXCR2
CXCL9 MIG 4q21.1 I IP10 Cxcl9 MIG 5qE3 I IP10 CXCR3, CXCR3B
CXCL10 IP-10 4q21.1 I IP10 Cxcl10 IP-10 5qE3 I IP10 CXCR3, CXCR3B
CXCL11 I-TAC 4q21.1 I IP10 Cxcl11 I-TAC 5qE3 I IP10 CXCR3, CXCR3B, CXCR7‡
CXCL12 SDF-1α/β 10q11.21 H   Cxcl12 SDF-1α/β 6qF1 H   CXCR4, CXCR7‡
CXCL13 BLC, BCA-1 4q21.1 H IP10 Cxcl13 BLC, BCA-1 5qE3 H IP10 CXCR5
CXCL14 BRAK, Bolekine 5q31.1 I   Cxcl14 BRAK 13qB2 I   Unknown
Unknown      Cxcl15 Lungkine, Weche 5qE2 U   Unknown
CXCL16   17p13.2 I   Cxcl16 Cxcl16 11qB4 I   CXCR6
CXCL17 DMC 19q13.2 U   Cxcl17 DMC 7qA3 U   Unknown
CC family
CCL1 I-309 17q11.2 I MCP Ccl1 TCA-3 11qB5 I MCP CCR8
CCL2 MCP-1 17q11.2 I MCP Ccl2 JE 11qB5 I MCP CCR2
CCL3 MIP-1α, LD78α 17q11.2 I MIP Ccl3* MIP-1α 11qB5 I MIP CCR1, CCR5
CCL3L1 LD78β 17q12 I MIP       
CCL3L3 LD78β 17q12 I MIP       
CCL4 MIP-1β 17q12 I MIP Ccl4* MIP-1β 11qB5 I MIP CCR5
CCL4L1 AT744.2 17q12 I MIP       
CCL4L2   17q12 I MIP       
CCL5 RANTES 17q12 I   Ccl5 RANTES 11qB5 I   CCR1, CCR3, CCR5
CCL7 MCP-3 17q11.2 I MCP Ccl7 MARC 11qB5   MCP CCR1, CCR2, CCR3
CCL8 MCP-2 17q11.2 I MCP Ccl8*, Ccl12* MCP-2, MCP-5 11qB5 I MCP CCR1, CCR2, CCR3, CCR5
CCL11 Eotaxin 17q11.2 I MCP Ccl11 Eotaxin 11qB5 I MCP CCR3
CCL13 MCP-4 17q11.2 I MCP Unknown     MCP CCR1, CCR2, CCR3
CCL14 HCC-1 17q12 H MIP Unknown      CCR1
CCL15 HCC-2 17q12 H MIP Ccl9 MMRP2, CCF18, MIP-1γ 11qB5 H MIP CCR1, CCR3
CCL16 HCC-4 LEC 17q12 H MIP Pseudogene   11qB5   MIP CCR1, CCR2, CCR5, HRH4§
CCL17 TARC 16q13 D MIP Ccl17 TARC 8qC5 D   CCR4
CCL18 PARC 17q12 H   Pseudogene      Unknown
CCL19 MIP3β, ELC 9p13.3 H   Ccl19 MIP3β 4qB1 H   CCR7
CCL20 MIP3α, LARC 2q36.3 D   Ccl20 MIP3α, LARC 1qC5 D   CCR6
CCL21 SLC 9p13.3 D   Ccl21a, Ccl21b, Ccl21c* SLC 4qB1 D   CCR7
CCL22 MDC 16q13 D   Ccl22 ABCD-1 8qC5 D   CCR4
CCL23 MPIF-1 17q12 I MIP Ccl6 C10 11qB5 I MIP CCR1, FPRL-1
CCL24 Eotaxin 2 7q11.23 I   Ccl24 Eotaxin 2 5qG1 I   CCR3
CCL25 TECK 19p13.2 H   Ccl25 TECK 8qA1.2 H   CCR9
CCL26 Eotaxin 3 7q11.23 I   Ccl26l Eotaxin 3-like 5qG1 I   CCR3
CCL27 CTACK, ILC 9p13.3 H   Ccl27a,b* CTACK, ILC 4qB1 H   CCR10
CCL28 MEC 5p12 U   Ccl28 MEC 13 U   CCR10, CCR3
Other classes
XCL1 Lymphotactin, SCM-1α 1q24.2 D   Xcl1* Lymphotactin 1qH2 D   XCR1
XCL2 SCM-1β 1q24.2 D        
CX3CL1 Fractalkine 16q13 I   Cx3cl1 Fractalkine 8qC5 I   CX3CR1
  1. Functions are as follows: I, inflammatory; H, homeostatic; D, dual (homeostatic and inflammatory); U, unknown. The lists of alternative names are not comprehensive. Chromosomal location data are derived from the Ensembl [39] or Mouse Genome Informatics [40] databases. GRO, GRO region of the CXC major gene cluster; IP10, IP10 region of the CXC major gene cluster; MCP, MCP region of the CC major gene cluster; MIP, MIP region of the CC major gene cluster. *See also Figure 2. †An alternatively spliced variant of CXCR3 that has been reported to mediate the ability of CXCL4, CXCL9, CXCL10 and CXCL11 to control angiogenesis. ‡Binding has been reported, but signaling is still controversial. §CCL16 has been reported to bind and signal through histamine receptor type 4. A splice variant of CCL23 has been reported to bind to and signal through formyl peptide receptor like-1 (FPRL-1).
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Genome Biology

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