Figure 3

The L2L application sequentially compares each list in the database with the input data, and records the overlap between the two lists of genes. (a) Each list in the database is a list of HUGO symbols. These are first translated to the corresponding microarray probes that represent those genes. Depending on the microarray, some genes on a list are represented by multiple probes and some by none at all. (b) The program finds the intersection between the translated list of probes from the database and the user's list of probes. The results are logged and written to a raw output file. The program then proceeds to the next list in the database. (c) Once all lists in the database have been compared with the user's data, the program creates a set of HTML pages to browse the output.