Figure 4

A comparison of the available human protein interaction data on the two benchmarks. (a) An examination of the initial performance of the datasets on the functional annotation test benchmark reveals the relative quality of each dataset. The interactions extracted using co-citation analysis filtered by the Bayesian estimator show a robust behavior in terms of their scores. (b) Comparison of the performance of the interactions retrieved from the co-citation analysis after incorporating the Bayesian filter and the interactions from HPRD and orthology transfer, as assessed on the physical interaction benchmark. The Bayesian filter effectively ranks the co-citation-derived interactions in terms of their correspondence to physical protein interactions.