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Table 1 Selenoprotein families identified in the Sargasso Sea database

From: The microbial selenoproteome of the Sargasso Sea

Prokaryotic selenoprotein family Unique sequences COG/Pfam ID COG/Pfam description
Known selenoproteins (209 sequences)
SelW-like protein 48 Pfam05169 Selenoprotein W-related
Peroxiredoxin (Prx) 43 COG1225 Peroxiredoxin
Proline reductase (PrdB) 42 -  
Selenophosphate synthetase 28 COG0709 Selenophosphate synthetase
Prx-like protein 22 COG0450 Peroxiredoxin-like
Thioredoxin (Trx) 11 COG3118 Thioredoxin
Formate dehydrogenase alpha chain (fdhA) 8 COG0243 Anaerobic dehydrogenases
Glutathione peroxidase (GPx) 5 COG0386 Glutathione peroxidase
Glycine reductase selenoprotein A (grdA) 1 -  
Glycine reductase selenoprotein B (grdB) 1 Pfam07355 Glycine reductase selenoprotein B
New selenoproteins (101 sequences)
AhpD-like protein 27 COG2128 Uncharacterized conserved protein
Arsenate reductase 14 COG1393 Arsenate reductase and related proteins
Molybdopterin biosynthesis MoeB protein 11 COG0476 Dinucleotide-utilizing enzymes, molybdopterin biosynthesis
Glutaredoxin (Grx) 10 COG0695 Glutaredoxin and related proteins
DsbA-like protein 9 COG2761 DsbA-like
Glutathione S-transferase 4 COG0625 Glutathione S-transferase
Deiodinase-like protein 4 Pfam00837 Iodothyronine deiodinase
Thiol-disulfide isomerase-like protein 4 -  
CMD domain-containing protein 4 Pfam02627 Carboxymuconolactone decarboxylase
Hypothetical protein 1 4 -  
Rhodanese-related sulfurtransferase 3 COG2897 Rhodanese-related sulfurtransferase
OsmC-like protein 3 COG1765 Predicted redox protein, OsmC-like
DsrE-like protein 2 Pfam02635 DsrE-like
DsbG-like protein 1 COG1651 DsbG, Protein-disulfide isomerase
NADH:ubiquinone oxidoreductase 1 COG2209 NADH:ubiquinone oxidoreductase
Total 310   
  1. Classification of selenoproteins (10 previously known and 15 new prokaryotic selenoprotein families) is supported by COG or Pfam sequence clusters (or both) as shown in this table. The number of individual selenoprotein sequences for each family is indicated.