Graphical overview of the permeome of P. falciparum. (a) Transport proteins with seven or more transmembrane domains (TMDs). These proteins were retrieved by the analysis of the genome using a computer program that interrogates a genome database on the basis of the hydropathy plots of the corresponding proteins . They include all the putative or known transport proteins with seven or more TMDs already identified in the genome, as well as 55 putative transport proteins with seven or more TMDs not previously recognized as such. (b) Transport proteins with six or fewer TMDs. These proteins were sourced in the most part from the annotated genome. Black bars, members of porter families (that is, uniporters, symporters and antiporters); dark-gray bars, members of primary active transporter families (that is, pumps); light-gray bars, members of channel families; white bars, putative transporters of unknown lineage and function. Abbreviations for the families are as follows: MFS, major facilitator superfamily; DMT, drug/metabolite transporter superfamily; ABC, ATP-binding cassette superfamily; P-ATPases, P-type ATPase superfamily; H+-PPases, H+-translocating pyrophosphatase family; MC, mitochondrial carrier family; CDF, cation diffusion facilitator family; F/V-ATPases, H+- or Na+-translocating F-type, V-type and A-type ATPase superfamily; ArsAB, arsenite-antimonite efflux family.