The alignment over the region of the selectivity sequence of the putative P. falciparum novel ion channel protein (PF14_0342) with a representative selection of K+ channel proteins (known and putative) of the voltage-gated ion channel superfamily. P. falciparum sequences are boxed and the protein designators highlighted. The P. yoelii homolog of the PF14_0342 protein is encoded by the chryPy1_00168 locus, which is available at PlasmoDB. For proteins of other organisms, the NCBI accession number and the known or putative (p) function of the protein are given. A larger alignment of the voltage-gated ion channel superfamily, encompassing transmembrane domains (TMDs) 2-6, is presented in Additional data file 9. Residues are shaded as follows: blue, positively charged,; red, negatively charged; orange, hydoxyl; gray, amido; green, proline; purple, cysteine; mid-blue, histidine,; light blue, glycine; olive green, tryptophan and tyrosine; yellow, remaining nonpolar.