Table 2 Isoforms of human VEGF-A
From: The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease
Isoform | Size (amino acids) | Coding exons* | Features |
|---|---|---|---|
VEGF-A121 | 121 | 1-5, 8 | Secreted |
VEGF-A145 | 145 | 1-6, 8 | Binds NRP2 but not NRP1; secreted |
VEGF-A165 | 165 | 1-5, 7, 8 | The most abundant and biologically active isoform; secreted; binds NRP1 and NRP2 |
VEGF-A165b | 165 | 1-5, 7, alternative exon 8 | Secreted, endogenous inhibitory form of VEGF-A165 |
VEGF-A183 | 183 | 1-5, short exon 6, 7, 8 | Sequestered in ECM but released by cleavage |
VEGF-A189 | 189 | 1-8 | Sequestered in ECM but released by cleavage |
VEGF-A206 | 206 | 1-8 plus additional exon 6-encoded sequence | Sequestered in ECM but released by cleavage |