DNA binding domain | Description | wTF2.0 | wTF1.0 | |||||
---|---|---|---|---|---|---|---|---|
 |  | WP140 22,420 | Family members in humans | Ortholog pairs | Clarke 1998 WP14 14,655 [16] | Ruvkun 1998 WP15 15,558 [15] | Rubin 2000 WP18 18,576 | Reichaman 2000 WP20 19,101 [18] |
AP-2 | Activator protein-2 | 4 | 5 | 0 | - | - | - | 4 |
ARID/BRIGHT | AT-rich interaction domain | 4 | 9 | 2 | - | - | - | 4 |
AT HOOK | Â | 31 | 28 | 5 | - | - | - | - |
BHLH | basic region helix loop helix | 42 | 103 | 22 | - | 24 | - | 25 |
BZIP | basic region leucine zipper | 32 | 57 | 11 | - | 18 | 18 | 25 |
CBF | CCAAT-binding factor | 9 | 12 | 7 | - | - | - | - |
COLD BOX | Â | 5 | 11 | 2 | - | - | - | - |
CP2 | Â | 1 | 6 | 1 | - | - | - | - |
HD | Homeodomain | 99 | 167 | 36 | - | 83 | 88 | 84 |
HMG | High mobility group | 16 | 59 | 12 | - | - | - | 15 |
HTH | Helix turn helix | 2 | 12 | 2 | - | - | - | - |
IPT/TIG | Ig-like, plexins, TFs | 3 | 8 | 2 | - | - | - | - |
MADF | Mothers against Dpp factor | 9 | 0 | 0 | - | - | - | - |
MADS box | MCM1/AG/DEF/SRF | 2 | 5 | 2 | - | - | - | 2 |
MH1 | MAD homology 1 | 7 | 12 | 1 | - | - | - | - |
MYB | Â | 19 | 21 | 8 | - | - | 16 | 3 |
p53 | Â | 3 | 3 | 1 | - | - | - | 0 |
PD-FULL | Paired domain | 5 | 9 | 1* | - | 5 | - | - |
PD-NPAX | Paired domain | 4 | 0 | 0 | - | - | - | - |
PD-CPAX | Paired domain | 1 | 0 | 0 | - | - | - | - |
PD-UNDEFINED | Paired domain | - | - | - | - | - | 11†| 10†|
RPEL | Â | 1 | 3 | 1 | - | - | - | - |
RUNT | Â | 1 | 6 | 1 | - | - | - | 1 |
SAND | Sp100, AIRE-1, NucP41/75, DEAF-1 | 4 | 8 | 1* | - | - | - | - |
STAT | Signal transducers and activators of transcription | 2 | 7 | 0 | - | - | - | 1 |
T-BOX | Â | 21 | 17 | 2 | - | 17 | - | 21 |
TEA/ATTS | Transcriptional enhancer activator | 1 | 4 | 1 | - | - | - | - |
TSC-22/DIP/BUN | Â | 3 | 4 | 0 | - | - | - | 1 |
WH-DAC | Dachshund | 1 | 2 | 1 | - | - | - | - |
WH-ETS | Erythroblast transformation specific | 10 | 15 | 5 | - | 10 | - | 10 |
WH-FH | Fork head | 18 | 41 | 4 | - | 15 | 19 | 15 |
WH-HSF | Heat shock factor | 2 | 8 | 1 | - | - | - | 1 |
WH-RFX | X-box binding regulatory factor | 1 | 3 | 0 | - | - | - | 1 |
WH-TDP | TF E2F dimerisation partner | 4 | 11 | 2 | - | - | - | 4 |
WH-UNDEFINED | Winged helix | 4 | 0 | 0 | - | - | - | - |
WT1 | Wilms tumor1 | 1 | 17 | 0 | - | - | - | - |
YL1 | Â | 1 | 1 | 1 | - | - | - | - |
ZF-A20 | Zinc finger, A20-type | 2 | 6 | 2 | - | - | - | - |
ZF-BED | BEAF/DREF-like ZF | 6 | 4 | 1 | - | - | - | - |
ZF-C2H2 | Â | 211 | 391 | 35 | 117 | - | 138 | 139 |
ZF-C2HC | Â | 1 | 6 | 1 | - | - | - | - |
ZF-CCCH | Â | 32 | 50 | 8 | 20 | - | - | 15 |
ZF-DHHC | Â | 15 | 21 | 7 | - | - | 13 | - |
ZF-DM | Dsx and Mab-3-like ZF | 11 | 7 | 0 | 8 | - | - | 9 |
ZF-FLYWCH | Â | 4 | 1 | 0 | - | - | - | - |
ZF-GATA | Â | 14 | 7 | 3 | 9 | - | - | 9 |
ZF-MIZ | Msx interacting ZF | 2 | 6 | 1 | - | - | - | - |
ZF-NF-X1 | Nuclear factor | 2 | 3 | 2 | - | - | - | - |
ZF-NHR/C4 | Nuclear hormone receptor | 274 | 43 | 6 | 233 | 235 | 224 | 252 |
ZF-THAP | Â | 5 | 12 | 2 | - | - | - | - |
UNKNOWN | Â | 5 | 0 | 2 | - | - | - | - |
TOTAL |  | 957‡ | 1,231 | 203 | 387 | 407 | 527 | 652 |