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Table 7 The most statistically significantly regulated functional groups in the fetal astrocyte cell lines based on their p values from t tests

From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

GO group GO identifier Number of probe sets p value Mean of GO group Mean of non-group members
Collagen GO:0005581 15 7.76E-07 0.33 -0.01
Endoplasmic reticulum GO:0005783 307 8.91E-07 0.03 -0.02
Fibrillar collagen GO:0005583 14 5.01E-06 0.29 -0.01
Intracellular non-membrane-bound organelle GO:0043232 122 7.94E-06 -0.06 -0.01
G-protein coupled receptor activity GO:0004930 141 1.26E-05 -0.09 -0.01
Gametogenesis GO:0007276 66 2.45E-05 -0.08 -0.01
Integral to plasma membrane GO:0005887 734 2.57E-05 -0.04 -0.01
Intramolecular oxidoreductase activity, interconverting keto- and enol-groups GO:0016862 11 2.19E-04 0.04 -0.01
Carbohydrate transport GO:0008643 16 2.40E-04 0.1 -0.01
DNA metabolism GO:0006259 309 3.98E-04 -0.04 -0.01
Extracellular matrix (sensu Metazoa) GO:0005578 120 6.76E-04 0.09 -0.02
Muscle development GO:0007517 82 6.76E-04 0.06 -0.01
Defense response GO:0006952 381 8.51E-04 -0.04 -0.01
Cell adhesion GO:0007155 227 8.91E-04 0.04 -0.01
MHC class II receptor activity GO:0045012 12 9.12E-04 -0.12 -0.01
  1. There were 734 functional groups tested. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between trisomy 21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ('non-group members'). After one type of multiple test comparison correction, the cut-off level for statistical significance was 6.81E-05 (assigned by dividing 0.05 by the number of functional groups, 734).