Figure 3
From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart
Increased transcript levels of genes assigned to chromosome 21 in TS21 samples compared to controls. The plots show ratio (TS21/euploid) of mean expression values, calculated using data from samples in each tissue or cell type, for all 23 chromosomes. (X and Y chromosome data were pooled.) The expression values were obtained with Affymetrix MAS5 software. The error bars represent standard errors (obtained by performing 1,000 iterations of a bootstrap resampling of the tissues). (a) The ratio of TS21 to euploid mean expression values for each chromosome in fetal cerebrum samples. (b) The ratio of TS21 to euploid mean expression values in fetal cerebellum samples. (c) The ratio of TS21 to euploid mean expression values in cultured astrocyte cell lines derived from fetal cerebrum tissues. (d) The ratio of TS21 to euploid mean expression values in fetal heart samples. (e) The ratio of TS21 to euploid mean expression values using data from all the above tissue and cell types.