Protein | Description | Domain of AP-2 proteins that interacts* | Function of interaction | Reference |
---|---|---|---|---|
APC | Adenomatous polyposis coli tumor suppressor | Basic region | Inhibition of β-catenin/TCF/LEF-dependent transcription | [16] |
CITED2 | Coactivator | DD | Transcriptional activation | [69] |
CITED4 | Coactivator | n.d. | Transcriptional activation | [70] |
CDP | CCAAT displacement protein | DBD, DD | Repression of the hamster histone H3.2 promoter | [71] |
DEK | Oncoprotein, chromatin remodeling | n.d. | Transcriptional activation | [72] |
E1A | Transforming protein of adenovirus | DBD, DD | Repression of AP-2 target genes | [73] |
c-Myc | Oncoprotein | Carboxyl terminus | Impairment of Myc/Max DNA-binding and transactivation | [14] |
PARP | PolyADP-ribose polymerase | Carboxyl terminus | Transcriptional activation | [74] |
PAX-6 | Transcription factor | n.d. | Stimulation of gelatinase B activation | [75] |
PC4 | Coactivator | Â | Transcriptional activation | [24] |
P300/CBP | Coactivator | Amino terminus | Transcriptional activation | [69] |
p53 | Tumor suppressor | n.d. | Augmentation of p53-dependent transcription | [76] |
RAP74 | Subunit of transcription factor TFIIF | Central region containing DBD | Unknown | [74] |
Rb | Retinoblastoma tumor suppressor | Amino terminus†| Repression of the hamster histone H3.2 promoter; transcriptional activation of the E-cadherin gene | [77,78] |
SP1 | Transcription factor | Basic region | Transcriptional activation of the ovine CYP11A1 gene | [79] |
SV40T | Transforming protein of SV40 virus | n.d. | Blocks DNA binding of AP-2 protein | [12] |
UBC9 | E2-conjugating enzyme | DBD, DD | Sumoylation | [80] |
WWOX | Tumor suppressor | Amino terminus PY motif | Cytoplasmic localization PPPY motif | [17] |
YB-1 | Transcription factor | n.d. | Stimulation of gelatinase A transcription | [81] |
YY1 | Transcription factor | DBD, DD | Stimulation of the hamster histone H3.2 promoter | [82] |