Figure 5

Domain interactions of Ras family members with nuclear pore proteins. (a) Yeast and worm Ran signal-transducing proteins interact with proteins that have Ran-binding domains [Pfam:PF00638, Ran_BP1], often found as components of nuclear pore complexes. Domain structures of the relevant interacting proteins are shown. Domains of proteins are colored boxes connected by a gray line. Protein names are in black to the left of each protein's domain structure schematic. Pfam-A domain names and Pfam-B accession numbers are the same color as the domains they label. Domain structures are schematic and are not to scale. (b) We find evidence for the interaction of a Pfam-B domain [Pfam:PB001470] the Ran_BP1 domain (E = 3.7). (c) Structural evidence [PDB:1RRP] [43] confirms that the domains PB001470 and Ran_BP1 interact, consistent with our prediction.