Figure 2

Examples of four of the 53 stability motifs discovered. M1 and M24 are destabilizing motifs, and M8 and M11 are stabilizing. Presented are mean half-life for each motif, and the p-value on the hypothesis that they mediate a significant increase or decrease in half-life compared with the genome, resulting from a ranksum test. Functional enrichment was tested as in Tavazoie et al. [5], hypergeometric p-values, and then applying FDR at q-value = 0.1. 'None' indicates that no GO term passed FDR.