Figure 1

mRNA half life distributions. (a) The mean half-life versus gene target set size of 50 stabilization-associated 3' UTR motifs. The genome mean is indicated by a blue line at 26.3 mins. Each stabilizing motif is marked with a red asterisk, and each de-stabilizing motif is marked by a green circle. Motif M1, which mediates a mean half-life of 16 mins for a target set of 641 genes, is not displayed in the figure. (b) Half-life distribution of the target gene sets of all destabilizing motifs (green), of target gene sets of all stabilizing motifs (red), and of all genes (blue).